Transcriptional control of cell fate specification by Mediator complex subunits during development

Henri-Marc BOURBON


DR CNRS
05 61 55 82 88

Team members

  Researcher
  • Muriel BOUBE
  • Henri-Marc BOURBON
  Professor
  • Emmanuelle GUILLOU
  Technical staff
  • Sandra BERNAT-FABRE

Presentation

The conserved multiprotein Mediator (MED) complex links DNA-bound transcription factors to RNA polymerase II (PolII). Despite a general role of Mediator in regulating nearly all PolII-dependent genes, studies from our and other labs have shown that a half of the 30 MED subunits have specific functions. Consistently, many human diseases have been linked to MED dysfunctions. Whereas most studies have been done from cultured cells, our team takes advantage of the Drosophila genetic model to investigate the molecular bases underlying the functional specificity of dedicated MED subunits in the transcriptional control of cell fate specification in-vivo.

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Funding

     

Université Paul Sabatier
118 Route de Narbonne

31062 TOULOUSE Cedex
France

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