Chromatin and Gene Expression

Kerstin Bystricky


Professeur, UPS
05 61 33 58 31

Team members

  Researcher
  • Anne-Claire Lavigne
  • Nicolas Tanguy Le Gac
  Professor
  • Silvia Kocanova
  Technical staff
  • Isabelle Goiffon
  • Fatima Moutahir
  • Flavien Raynal
  Postdoc
  • Noémie Kempf
  PhD
  • Thomas Germier
  • Ludmila Recoules

Presentation

We want to get a high resolution climpse at chromatin structure and chromosome behavior with respect to fundamental aspects of double strand break processing, transcription activation and viral infection. We develop methods to label DNA in fixed and living cells using fluorescent probes and develop non-invasive labeling techniques to visualize and quantify DNA. The technology transfer from yeast to human cells is an asset in the laboratory, and opens new perspectives in the field of chromatin dynamics. Applying mathematical modeling, we attempt to elucidate the functional relationship between the location of a gene, its inherent dynamics and its response to stimuli. We explore kinetics of long range chromatin interactions in order to obtain new structural insights on chromatin organization based on physical parameters. We analyse epigenetic mechanisms of gene expression in mammary tumor cells, investigating in particular the chromatin structure and its modifications at estrogen receptor target genes, and biophysical properties of chromosomes and their role in DNA double strand break repair in yeast. Our challenge is to experimentally act upon structure to probe impact on function.
 

 

 

Projets

Chromatin dynamics and regulation of gene expression

Cancer chromatin signatures – role of histone variants

Chromosome dynamics and DNA repair

Publications

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Funding

             

SATT Toulouse Tech transfert

Alumni

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Université Paul Sabatier
118 Route de Narbonne

31062 TOULOUSE Cedex
France

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