Imprinted small non-coding RNAs

Jérôme Cavaille


DR CNRS
05 61 33 59 34

Team members

  Research engineer
  • Marie-Line Bortolin
  • Virginie Marty
  • Baptiste Grand
  Researcher
  • Jérôme Cavaille
  Associate professor
  • Patrice Vitali
  PhD student
  • Julie Riviere

Presentation

Our research focuses on hundreds small noncoding RNAs belonging to the microRNA and C/D snoRNA families. These genes map to chromosomal regions regulated by genomic imprinting, an epigenetic phenomenon by which a few genes are mono-allelically expressed in a parent-of-origin specific manner. The rationale of our research is to explore the impact of recently evolved, imprinted small RNA genes on the evolution, expression and function of mammalian genomes, including in pathological contexts such as the Prader-Willi syndrome.

Projets

Imprinted C/D snoRNA genes at the PWS locus

Imprinted miRNA genes at the Dlk1-Dio3 locus

Imprinted miRNA genes at the C19MC locus

Publications

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Funding

   

Fondation for Prader-Willi research

Ligue Régionale contre le Cancer

Université Paul Sabatier
118 Route de Narbonne

31062 TOULOUSE Cedex
France


05 61 33 58 00

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