Chromatin Dynamics and Cell Proliferation

Olivier CUVIER


Chargé de Recherche, INSERM
05 61 33 59 56

Team members

  Researcher
  • Laurent LACROIX
  • Stéphane SCHAAK
  Professor
  • Raphael MOURAD
  Technical staff
  • Charlène PERROIS
  PhD
  • Julien ANGLADE
  • Alexandre HEURTEAU
  Master Student
  • Mahdia ABDI GALAB
  • David DEPIERRE

Presentation

We study how chromatin dynamics govern cell fate/proliferation through:

a) Nucleosome-positioning, which controls the accessibility of key genomic features such as gene promoters/bodies or replication origins.

b) Higher-order chromatin folding for the regulation of transcription/replication, which involves DNA looping to mediate long-range interactions between distinct/functional elements.

We investigate how specific chromatin modifiers (Mes-4/NSD, Hypb etc.), regulators (insulator and co-factors), and oncogenes (dref, …) impact transcription or replication through chromatin dynamics.

To this end, we employ biochemistry, molecular genetics, cellular biology combined with computational biology of high throughput sequencing data to tackle key aspects of chromatin organization. 

https://www-lbme.biotoul.fr/uk/equipes/grpcuvier/index.html

 

Projets

HiCfeat

G4Hunter

Chromatin-based clonal inheritance

Chromatin dynamics

Publications

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Université Paul Sabatier
118 Route de Narbonne

31062 TOULOUSE Cedex
France

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