Chromatin Dynamics and Cell Proliferation

Olivier CUVIER

Chargé de Recherche, INSERM
05 61 33 59 56

Team members

  • Laurent LACROIX
  • Stéphane SCHAAK
  • Raphael MOURAD
  Technical staff
  • Charlène PERROIS
  • Alexandre HEURTEAU
  Master Student
  • Mahdia ABDI GALAB
  • David DEPIERRE


We study how chromatin dynamics govern cell fate/proliferation through:

a) Nucleosome-positioning, which controls the accessibility of key genomic features such as gene promoters/bodies or replication origins.

b) Higher-order chromatin folding for the regulation of transcription/replication, which involves DNA looping to mediate long-range interactions between distinct/functional elements.

We investigate how specific chromatin modifiers (Mes-4/NSD, Hypb etc.), regulators (insulator and co-factors), and oncogenes (dref, …) impact transcription or replication through chromatin dynamics.

To this end, we employ biochemistry, molecular genetics, cellular biology combined with computational biology of high throughput sequencing data to tackle key aspects of chromatin organization.





Chromatin-based clonal inheritance

Chromatin dynamics


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Université Paul Sabatier
118 Route de Narbonne

31062 TOULOUSE Cedex

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