Chromatin Dynamics and Cell Proliferation

Olivier Cuvier

Chargé de Recherche, INSERM
05 61 33 59 56

Team members

  Researcher
  • Stéphane Schaak
  Professor
  • Raphael Mourad
  Technical staff
  • Julien Anglade
  • Charlène Perrois
  PhD
  • David Depierre
  • Alexandre Heurteau
  Master Student
  • Ségolène Augé
  • Benjamin Le Bozec

Presentation

We study how chromatin dynamics govern cell fate/proliferation through:

a) Nucleosome-positioning, which controls the accessibility of key genomic features such as gene promoters/bodies or replication origins.

b) Higher-order chromatin folding for the regulation of transcription/replication, which involves DNA looping to mediate long-range interactions between distinct/functional elements.

We investigate how specific chromatin modifiers (Mes-4/NSD, Hypb etc.), regulators (insulator and co-factors), and oncogenes (dref, …) impact transcription or replication through chromatin dynamics.

To this end, we employ biochemistry, molecular genetics, cellular biology combined with computational biology of high throughput sequencing data to tackle key aspects of chromatin organization. 

https://www-lbme.biotoul.fr/uk/equipes/grpcuvier/index.html

 

 

Projets

HiCfeat

G4Hunter

Chromatin-based clonal inheritance

Chromatin dynamics

Publications

View all publications

Funding

       

Alumni

Laurent Lacroix

Priscillia Lhoumaud

Pascal Martin

Gael Micas

Sophie Queille

Université Paul Sabatier
118 Route de Narbonne

31062 TOULOUSE Cedex
France

Annuaire général