Chromatin Dynamics and Cell Proliferation

Olivier Cuvier

Directeur de Recherche, INSERM
05 61 33 59 56

Team members

  • Stéphane Schaak
  Technical staff
  • Julien Anglade
  • Charlène Perrois
  • David Depierre
  • Alexandre Heurteau
  Master Student
  • Olivier Fosseprez


We study how chromatin dynamics govern cell fate/proliferation through:

a) Nucleosome-positioning, which controls the accessibility of key genomic features such as gene promoters/bodies or replication origins.

b) Higher-order chromatin folding for the regulation of transcription/replication, which involves DNA looping to mediate long-range interactions between distinct/functional elements.

We investigate how specific chromatin modifiers (Mes-4/NSD, Hypb etc.), regulators (insulator and co-factors), and oncogenes (dref, …) impact transcription or replication through chromatin dynamics.

To this end, we employ biochemistry, molecular genetics, cellular biology combined with computational biology of high throughput sequencing data to tackle key aspects of chromatin organization.






Chromatin-based clonal inheritance

Chromatin dynamics


View all publications




Raphaël Mourad (Maître de Conférence)

Jun Liang (Assistant Professor)

Priscillia Lhoumaud (Postdoctoral researcher)

Laurent Lacroix (Chargé de Recherche)

Franck Court (Chargé de Recherche)

Emmanuelle Guillou (Maître de Conférence)

Eldon Emberly (Associate Professor)

Pascal Martin (Ingénieur de Recherche)

Gael Micas

Sophie Queille

Université Paul Sabatier
118 Route de Narbonne

31062 TOULOUSE Cedex

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