Cell-cell communication in the mammalian nervous system
DR CNRS 05 61 55 75 51
Research in the team focuses on elucidating mechanisms that govern development of the nervous system and how genetic alterations of this complex developmental program may lead to brain disease in the adult. We investigate cell-to-cell communication via the Eph/ephrin signaling pathway, mostly in the context of neurogenesis and neural progenitor specification and maintenance. Our studies combine in vivo experimentations on genetic mouse models, ex vivo experimentations on tissue explants and in vitro cultures of primary neural progenitors, brain tumor stem cells and cell lines.
Duquesnes N, Callot C, Jeannot P, Daburon V, Nakayama KI, Manenti S, Davy A, Besson A.. p57(Kip2) knock-in mouse reveals CDK-independent contribution in the development of Beckwith-Wiedemann syndrome. J. Pathol. 239(3):250-61 2016 May
Defourny J, Delacroix L, Mateo Sánchez S, Schoonaert L, Robberecht W, Davy A, Nguyen L and Malgrange B. (2015) Direct transdifferentiation and integration into cochlear hair cell layers by inhibition of ephrin-B2 signalling. Nat. Comm. 6:7017. 2015 Jun