Cell-cell communication in the mammalian nervous system

Alice DAVY

05 61 55 75 51

Team members

  • Catherine LECLERC
  • Isabelle NEANT
  Technical staff
  • Christophe AUDOUARD
  • Thomas JUNGAS
  Postdoctoral fellow
  • Mohamad-Ali FAWAL


Research in the team focuses on elucidating mechanisms that govern development of the nervous system and how genetic alterations of this complex developmental program may lead to brain disease in the adult. 
We investigate cell-to-cell communication via the Eph/ephrin signaling pathway, mostly in the context of neurogenesis and neural progenitor specification and maintenance. Our studies combine in vivo experimentations on genetic mouse models, ex vivo experimentations on tissue explants and in vitro cultures of primary neural progenitors, brain tumor stem cells and cell lines.  


Calcium signaling

Elaborating a theoretical framework of neocortex development

Exploring parallels between neural progenitors and brain tumor stem cells

Investigating specification of neural progenitor fates


  • Fawal MA and Davy A.
    Impact of Metabolic Pathways and Epigenetics on Neural Stem Cells.
    Epigenetics Insights
    2019 Jan
  • Isabelle Néant, Jacques Haiech, Marie-Claude Kilhoffer, Francisco J. Aulestia, Marc Moreau, Catherine Leclerc.
    Ca2+-dependent transcriptional repressors KCNIP and regulation of prognosis genes in glioblastoma.
    Frontiers in Molecular Neuroscience
    2018 Dec
  • Aulestia FJ, Néant I, Dong J, Haiech J, Kilhoffer MC, Moreau M, Leclerc C..
    Quiescence status of glioblastoma stem-like cells involves remodelling of Ca2+ signalling and mitochondrial shape.
    Scientific Reports
    2018 Jul
  • Fawal MA, Jungas T, Kischel A, Audouard C, Iacovoni JS and Davy A.
    Crosstalk between one carbon metabolism, eph signaling and histone methylation promotes neural stem cells differentiation
    Cell Reports
    2018 Jun Access the recommendation on F1000Prime
  • Mire E, Hocine M, Bazellières E, Jungas T, Davy A, Chauvet S, Mann F..
    Developmental Upregulation of Ephrin-B1 Silences Sema3C/Neuropilin-1 Signaling during Post-crossing Navigation of Corpus Callosum Axons.
    Current Biology
    2018 May

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KISCHEL Anthony (PhD 2015-2019)

LAUSSU Julien (PhD 2011-2015)> postdoc CRBM, Montpellier, France

ARVANITIS Constandina (postdoc 2007-2010, CR1 2010-2014)> I2MC, Toulouse

LUXEY Maëva (PhD 2007-2011)> Project leader Basel University, Switzerland

BEHAR Annie, AI (CDD 2008-2010)

Université Paul Sabatier
118 Route de Narbonne

31062 TOULOUSE Cedex

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