Cell-cell communication in the mammalian nervous system
DR CNRS 05 61 55 75 51
Research in the team focuses on elucidating mechanisms that govern development of the nervous system and how genetic alterations of this complex developmental program may lead to brain disease in the adult. We investigate cell-to-cell communication via the Eph/ephrin signaling pathway, mostly in the context of neurogenesis and neural progenitor specification and maintenance. Our studies combine in vivo experimentations on genetic mouse models, ex vivo experimentations on tissue explants and in vitro cultures of primary neural progenitors, brain tumor stem cells and cell lines.
Fawal MA and Davy A. Impact of Metabolic Pathways and Epigenetics on Neural Stem Cells. Epigenetics Insights 2019 Jan
Isabelle Néant, Jacques Haiech, Marie-Claude Kilhoffer, Francisco J. Aulestia, Marc Moreau, Catherine Leclerc. Ca2+-dependent transcriptional repressors KCNIP and regulation of prognosis genes in glioblastoma. Frontiers in Molecular Neuroscience 2018 Dec
Aulestia FJ, Néant I, Dong J, Haiech J, Kilhoffer MC, Moreau M, Leclerc C.. Quiescence status of glioblastoma stem-like cells involves remodelling of Ca2+ signalling and mitochondrial shape. Scientific Reports 2018 Jul
Mire E, Hocine M, Bazellières E, Jungas T, Davy A, Chauvet S, Mann F.. Developmental Upregulation of Ephrin-B1 Silences Sema3C/Neuropilin-1 Signaling during Post-crossing Navigation of Corpus Callosum Axons. Current Biology 2018 May