Mechanisms of chromatin patterning
ChargÃ© de Recherche, CNRS
05 61 33 58 60
Inspired by the functional diversity among the genetically identical cells of an organism, our goal is to understand how cells can interpret their genome in a particular way to establish their cellular identity. To this end, we study the mechanisms that cells use to form and maintain cell type-specific chromatin patterns along their genome. As these patterns span multiple scales from a few modified histones to micron-sized subcompartments, we investigate them using complementary techniques from single-molecule biophysics to live-cell imaging. Further information will be available soon as the lab is growing.
- Erdel F, Rippe K.
Formation of chromatin subcompartments by phase separation
Biophys J 114(10):2262-70
- Rademacher A, Erdel F, Trojanowski J, Schumacher S, Rippe K.
Real-time observation of light-controlled transcription in living cells
J Cell Sci 130(24):4213-24
- Erdel F.
How communication between nucleosomes enables spreading and epigenetic memory of histone modifications
- Molitor J, Mallm JP, Rippe K, Erdel F.
Retrieving chromatin patterns from deep sequencing data using correlation functions
Biophys J 112(3):473-490
- Erdel F, Kratz K, Willcox S, Griffith JD, Greene EC, de Lange T.
Telomere Recognition and Assembly Mechanism of Mammalian Shelterin
Cell Rep 18(1):41-53
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