Roland Barriot Assistant professor, University P. Sabatier
Michael Chandler DR Emeritus
Petra Langendijk-Genevaux IE2, CNRS
Gwennaele Fichant Professor, University Paul Sabatier
Our team studies the molecular mechanisms involved in the adaptation processes of procaryotic genomes through comparative genomics and phylogenomics. We develop strategies to identify, reconstruct and classify, from the genomic sequences, functional supra-molecular assemblies and phylogenomics approaches, based on graph partitioning methods, to identify evolutionary relationships between genes/proteins and assemblies. We apply our approaches to conduct evolutionary analyses on diverse families of biological systems. In addition, we are also interested in the dynamics of the interaction between biological entities and focus, as sufficient experimental data are available, on the dynamic modeling of competence regulation during bacterial transformation in S. pneumoniae.
2015 Jan Clouet-d'Orval B, Phung DK, Langendijk-Genevaux PS, Quentin Y. (2015) Universal RNA-degrading enzymes in Archaea: Prevalence, activities and functions of β-CASP ribonucleases. Biochimie. 2015 Jun 6. pii: S0300-9084(15)00171-6. doi:10.1016/j.biochi.2015.05.021. [Epub ahead of print] Review. PubMed PMID:26054421.
2015 Jan Aït-Bara S, Carpousis AJ, Quentin Y. (2015) RNase E in the γ-Proteobacteria: conservation of intrinsically disordered noncatalytic region and molecular evolution of microdomains. Mol Genet Genomics. 290(3):847-62. doi:10.1007/s00438-014-0959-5. Epub 2014 Nov 29.
2014 Jan Johnston, C., Martin, B., Fichant, G., Polard, P. and Claverys, J.P. (2014). Bacterial transformation: distribution, shared mechanisms and divergent control. Nat Rev Microbiol. 12(3):181-96.
2013 Jan Mirouze N, Bergé MA, Soulet AL, Mortier-Barrière I, Quentin Y, Fichant G, Granadel C, Noirot-Gros MF, Noirot P, Polard P, Martin B, Claverys JP (2013). Direct involvement of DprA, the transformation-dedicated RecA loader, in the shut-off of pneumococcal competence. Proc Natl Acad Sci U S A. 110(11):E1035-44.
2013 Jan Phung DK, Rinaldi D, Langendijk-Genevaux PS, Quentin Y, Carpousis AJ, Clouet-d'Orval B. (2013). Archaeal β-CASP ribonucleases of the aCPSF1 family are orthologs of the eukaryal CPSF-73 factor. Nucleic Acids Res. 41(2):1091-103.