Genomics of integrated systems

Gwennaele Fichant

Professeur, UPS
05 61 33 58 26

Team members

  Researcher emeritus
  • Michael Chandler
  • Yves Quentin
  • Roland Barriot
  Technical staff
  • Petra Langendyk Genevaux


Yves Quentin Roland Barriot Michael Chandler Petra Langendijk-Genevaux Gwennaele Fichant

Yves Quentin
Roland Barriot
Assistant professor, University P. Sabatier
Michael Chandler
DR Emeritus
Petra Langendijk-Genevaux
Gwennaele Fichant
Professor, University Paul Sabatier


Our team studies the molecular mechanisms involved in the adaptation processes of procaryotic genomes through comparative genomics and phylogenomics. We develop strategies to identify, reconstruct and classify, from the genomic sequences, functional supra-molecular assemblies and phylogenomics approaches, based on graph partitioning methods, to identify evolutionary relationships between genes/proteins and assemblies. We apply our approaches to conduct evolutionary analyses on diverse families of biological systems. In addition, we are also interested in the dynamics of the interaction between biological entities and focus, as sufficient experimental data are available, on the dynamic modeling of competence regulation during bacterial transformation in S. pneumoniae


Dynamic modeling of competence regulation during bacterial transformation in S. pneumoniae



  • Clouet-d'Orval B, Batista M, Bouvier M, Quentin Y, Fichant G, Marchfelder A, Maier LK.
    Insights into RNA processing pathways and associated-RNA degrading enzymes in Archaea.
    FEMS Microbiol Rev.
    2018 Apr DOI:10.1093/femsre/fuy016
  • El Mortaji L, Aubert S, Galtier E, Schmitt C, Anger K, Redko Y, Quentin Y, De Reuse H..
    The Sole DEAD-Box RNA Helicase of the Gastric Pathogen Helicobacter pylori Is Essential for Colonization.
    MBio. 2018 Mar 27;9(2). pii: e02071-17.
    2018 Mar doi: 10.1128/mBio.02071-17.
  • Jamet S, Quentin Y, Coudray C, Texier P, Laval F, Daffé M, Fichant G, Cam K..
    Evolution of Mycolic Acid Biosynthesis Genes and Their Regulation during Starvation in Mycobacterium tuberculosis.
    J Bacteriol. 2015 Dec; 197(24):3797-811.
    2015 Dec doi: 10.1128/JB.00433-15.
  • 2015 Jan Clouet-d'Orval B, Phung DK, Langendijk-Genevaux PS, Quentin Y. (2015) Universal RNA-degrading enzymes in Archaea: Prevalence, activities and functions of β-CASP ribonucleases. Biochimie. 2015 Jun 6. pii: S0300-9084(15)00171-6. doi:10.1016/j.biochi.2015.05.021. [Epub ahead of print] Review. PubMed PMID:26054421.
  • 2015 Jan Aït-Bara S, Carpousis AJ, Quentin Y. (2015) RNase E in the γ-Proteobacteria: conservation of intrinsically disordered noncatalytic region and molecular evolution of microdomains. Mol Genet Genomics. 290(3):847-62. doi:10.1007/s00438-014-0959-5. Epub 2014 Nov 29.

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Mathias WEYDER
Bénédicte WIRTH
Marie-Jeanne BASSE

Université Paul Sabatier
118 Route de Narbonne

31062 TOULOUSE Cedex

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