Genomics of integrated systems

Gwennaele Fichant


PR UPS
05 61 33 58 26

Team members

  Professor
  • Gwennaele Fichant
  LMGM

Research programs

Presentation

Biological systems result from a complex evolutionary history, as partners and/or relationships between them may have been gained, lost or replaced during evolution. Our main research interest is to use genomic data to clarify the history that shaped key cellular process (ancestral genes, horizontal gene transfers, gene gains/losses) but also to provide functional information for experimental work. We address these issues by conducting comparative genomic analyses with phylogenomics approaches.

Genomics of Integrated SYstems team Fichant

For several years, through different collaborations with experimental biologists, we have focused our studies on the evolution of RNA degradation and processing machineries in bacteria and archaea by conducting many phylogenomics analyses on the different partners (ribonuclease, helicases, …). More recently, we have initiated a collaboration with Peter Redder's group to understand RNase J-mediated RNA degradation in Firmicutes with S. aureus as a model organism, and to assess the contribution of secondary structures and 5' epi-transcriptomic modifications of RNA substrates to the regulation of this process. In addition to phylogenomics approaches on the partners of the degradation machinery, this project focuses on RNA substrates and requires the development of original workflows and statistical analyses to integrate the specificity of the RNA-Seq data produced by P. Redder's team.

LMGM

Quentin_YvesBarriot_RolandLangendijk-Genevaux_PetraCaetano Tomas
Gwennaele Fichant
Professor, UT3
Yves Quentin
Researcher, CNRS
Roland Barriot
Associate Professor, UT3
Petra Langendijk-Genevaux
Engineer, CNRS
Tomas Caetano
PhD student, UT3

Projets

Genome-wide analyses of multigenic families

RNA homeostasis in Firmicutes

RNA processing machineries in Archaea

Publications

View all publications

Funding

     

Alumni

Kathy DE SOUSA
Michael CHANDLER
Mathias WEYDER
Arnaud FRECHE
Virginie CALDERON
Claire GAUGAIN
Bénédicte WIRTH
Marie-Jeanne BASSE

Université Paul Sabatier
118 Route de Narbonne

31062 TOULOUSE Cedex
France


05 61 33 58 00

Annuaire général