Gwennaele Fichant Professor, University Paul Sabatier
Yves Quentin CR1, CNRS
Roland Barriot Assistant professor, University P. Sabatier
Petra Langendijk-Genevaux IE, CNRS
Kathy De Sousa CDD IE, CNRS
Our team studies the molecular mechanisms involved in the adaptation processes of procaryotic genomes through comparative genomics and phylogenomics. We develop strategies to identify, reconstruct and classify, from the genomic sequences, functional supra-molecular assemblies and phylogenomics approaches, based on graph partitioning methods, to identify evolutionary relationships between genes/proteins and assemblies. We apply our approaches to conduct evolutionary analyses on diverse families of biological systems. In addition, we are also interested in the dynamics of the interaction between biological entities and focus, as sufficient experimental data are available, on the dynamic modeling of competence regulation during bacterial transformation in S. pneumoniae.
Weyder M, Prudhomme M, Bergé M, Polard P, Fichant G.. Dynamic Modeling of Streptococcus pneumoniae Competence Provides Regulatory Mechanistic Insights Into Its Tight Temporal Regulation Front Microbiol 2018 Jul 9:1637. doi:10.3389/fmicb.2018.01637.
Quentin Y, Siguier P, Chandler M, Fichant G.. Single-strand DNA processing: phylogenomics and sequence diversity of a superfamily of potential prokaryotic HuH endonucleases BMC Genomics 2018 Jun 19(1):475. doi:10.1186/s12864-018-4836-1.
Clouet-d'Orval B*, Batista M, Bouvier M, Quentin Y, Fichant G, Marchfelder A, Maier LK. Insights into RNA processing pathways and associated-RNA degrading enzymes in Archaea. FEMS Microbiol Rev. 2018 Apr DOI:10.1093/femsre/fuy016
El Mortaji L, Aubert S, Galtier E, Schmitt C, Anger K, Redko Y, Quentin Y, De Reuse H.. The Sole DEAD-Box RNA Helicase of the Gastric Pathogen Helicobacter pylori Is Essential for Colonization. MBio. 2018 Mar 27;9(2). pii: e02071-17. 2018 Mar doi: 10.1128/mBio.02071-17.
Jamet S, Quentin Y, Coudray C, Texier P, Laval F, Daffé M, Fichant G, Cam K.. Evolution of Mycolic Acid Biosynthesis Genes and Their Regulation during Starvation in Mycobacterium tuberculosis. J Bacteriol. 2015 Dec; 197(24):3797-811. 2015 Dec doi: 10.1128/JB.00433-15.