Molecular Chaperone Networks

Pierre Genevaux

Chargé de Recherche, CNRS
05 61 33 58 73

Team members

  Researcher emeritus
  • Olivier Fayet
  • Patricia Bordes
  • Marie-Pierre Castanie
  • Marie-Françoise Prere
  Technical staff
  • Anne-Marie Cirinesi
  • Michèle Coddeville
  • Ola Al-Fawares
  • Moise Mansour


The Molecular Chaperone Networks research group at the Laboratory of Microbiology and Molecular genetics (LMGM-CBI) mainly focuses on the biology of molecular chaperone machines in bacteria. Genetics, molecular biology and biochemistry technics are used to identify new molecular chaperone functions and to pin point key interplay between major chaperones, such as DnaK/HSP70, DnaJ/HSP40, GroEL/HSP60, Trigger Factor or SecB, and other bacterial stress proteins, including Toxin-Antitoxin systems (see Figure). More recently, we have focused on SecB-like molecular chaperones in the human pathogen M. tuberculosis and revealed for the first time the control of a stress-responsive Toxin-Antitoxin system by molecular chaperones. 



  • Fréderic Angles, Marie-Pierre Castanie-Cornet, Nawel Slama, Mickael Dinclaux, Anne-Marie Cirinesi, Jean-Charles Portais, Fabien Letisse and Pierre Genevaux.
    Multilevel interaction of the DnaK/DnaJ(HSP70/HSP40) stress-responsive chaperone machine with the central metabolism
    Sci. Rep
    2017 Jan
  • Bordes P, Sala AJ, Ayala S, Texier P, Slama N, Cirinesi AM, Guillet V, Mourey L, Genevaux P.
    Chaperone addiction of toxin-antitoxin systems
    Nat Commun
    2016 Nov
  • Schlegel S, Genevaux P, de Gier JW.
    Isolating Escherichia coli strains for recombinant protein production
    Cell Mol Life Sci
    2016 Oct
  • Garcie C, Tronnet S, Garénaux A, McCarthy AJ, Brachmann AO, Pénary M, Houle S, Nougayrède JP, Piel J, Taylor PW, Dozois CM, Genevaux P, Oswald E, Martin P.
    The Bacterial Stress-Responsive Hsp90 Chaperone (HtpG) Is Required for the Production of the Genotoxin Colibactin and the Siderophore Yersiniabactin in Escherichia coli
    J Infect Dis
    2016 Sep
  • Ruiz-González MX, Czirják GÁ, Genevaux P, Møller AP, Mousseau TA, Heeb P.
    Resistance of Feather-Associated Bacteria to Intermediate Levels of Ionizing Radiation near Chernobyl
    Sci. Rep
    2016 Mar

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Université Paul Sabatier
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