Haematopoiesis & Immunity

Marc HAENLIN

DR CNRS
05 61 55 68 23

Team members

  Researcher
  • Vanessa GOBERT
  • Fernando ROCH
  Technical staff
  • Benoît AUGE
  PhD
  • Aichun CHEN
  • Thomas GENAIS

Presentation

Our main axis of research aims at understanding how blood cell development is controlled under normal or pathological conditions using Drosophila as a model system. In particular we study how GATA and RUNX transcription factors control cell fate choice and differentiation during haematopoiesis and leukaemia. Moreover, we are interested in deciphering the regulation of Drosophila larval and adult hematopoietic system homeostasis by genetic and environmental cues.

In parallel, we analyze the biological properties of Ly6 protein family members. We investigate their mechanism of action during paracellular barrier formation in Drosophila and the mechanisms underlying their functional diversification during insect evolution.

Projets

Control of larval and adult haematopoietic system homeostasis

Control of larval and adult haematopoietic system homeostasis

GATA and RUNX transcription factors during haematopioesis and leukaemia

Publications

  • 2015 Jul Tanaka K, Diekmann Y, Hazbun A, Hijazi A, Vreede B, Roch F, Sucena É. Multispecies Analysis of Expression Pattern Diversification in the Recently Expanded Insect Ly6 Gene Family. Mol Biol Evol. 2015 Jul;32(7):1730-47
  • 2015 Jan Benmimoun B, Polesello C, Haenlin M, Waltzer L. The EBF transcription factor Collier directly promotes Drosophila blood cell progenitor maintenance independently of the niche. PNAS 2015 Jul 6. pii: 201423967.
  • Benmimoun B, Haenlin M, Waltzer L..
    Blood cell progenitor maintenance: Collier barks out of the niche.
    Fly
    2015 Jan
  • 2014 Jan Breig O, Bras S, Martinez Soria N, Osman D, Heidenreich O, Haenlin M, Waltzer L Pontin is a critical regulator for AML1-ETO-induced leukemia. Leukemia. 2014 ;28(6) : 1271-9.
  • 2012 Jan Benmimoun B, Polesello C, Waltzer L, Haenlin M. Dual role for Insulin/TOR signaling in the control of hematopoietic progenitor maintenance in Drosophila. Development. 2012 ;139(10):1713-7

View all publications

Université Paul Sabatier
118 Route de Narbonne

31062 TOULOUSE Cedex
France

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