Small nuclear regulatory RNAs

Tamas KISS

Directeur de Recherche, INSERM
05 61 33 59 07

Team members

  Researcher
  • Sylvain EGLOFF
  • Béata JADY
  Professor
  • Patrice VITALI
  Technical staff
  • Amandine KETELE
  PhD
  • Cécilia STUDNIAREK
  Master Student
  • Lucie MARTIN

Presentation

The nuclei of human cells contain an enormous number of small nuclear regulatory RNAs (snRNAs) which, in the forms of small nuclear ribonucleoproteins (snRNPs), function in all aspects of gene expression. Our research focuses on the understanding of the structural and functional complexity, the biogenesis and intracellular trafficking of human snRNPs. In the past, we have described and functionally characterized several novel groups of human snRNPs. Recently, we are dissecting the complex transcriptional regulatory function of the 7SK snRNP that controls RNA polymerase II activity. We also study the biogenesis and function of a novel class of snRNAs, the AluACA RNAs, which are processed from intronic Alu repetitive sequences.

Projets

Expression and packaging of AluACA RNAs into box H/ACA RNPs

Controlling RNA polymerase II transcription by the 7SK snRNP

Publications

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Université Paul Sabatier
118 Route de Narbonne

31062 TOULOUSE Cedex
France

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