Small nuclear regulatory RNAs
Directeur de Recherche, INSERM
05 61 33 59 07
Researcher Professor Technical staff PhD
The nuclei of human cells contain an enormous number of small nuclear regulatory RNAs (snRNAs) which, in the forms of small nuclear ribonucleoproteins (snRNPs), function in all aspects of gene expression. Our research focuses on the understanding of the structural and functional complexity, the biogenesis and intracellular trafficking of human snRNPs. In the past, we have described and functionally characterized several novel groups of human snRNPs. Recently, we are dissecting the complex transcriptional regulatory function of the 7SK snRNP that controls RNA polymerase II activity. We also study the biogenesis and function of a novel class of snRNAs, the AluACA RNAs, which are processed from intronic Alu repetitive sequences.
Expression and packaging of AluACA RNAs into box H/ACA RNPs
Controlling RNA polymerase II transcription by the 7SK snRNP
- Egloff S, Vitali P, Tellier M, Raffel R, Murphy S, Kiss T.
The 7SK snRNP associates with the little elongation complex to promote snRNA gene expression.
EMBO J., 36, 934-948.
- Ketele A, Kiss T, Jady BE..
Human intron-encoded AluACA RNAs and telomerase RNA share a common element promoting RNA accumulation.
RNA Biol., 13, 1274-1285.
- Zaborowska J, Egloff S, Murphy S..
The pol II CTD: new twists in the tail.
Nat Struct Mol Biol., 23, 771-777.
- Marnef A, Jady BE, Kiss T..
Human polypyrimidine tract-binding protein interacts with mitochondrial tRNA(Thr) in the cytosol.
Nucleic Acids Res., 44, 1342-53.
- Laitem C, Zaborowska J, Tellier M, Yamaguchi Y, Cao Q, Egloff S, Handa H, Murphy S..
CTCF regulates NELF, DSIF and P-TEFb recruitment during transcription.
Transcription, 6, 79-90.
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