Role of cell cycle in cell fate decision


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Team members

  • Eric AGIUS
  • Sophie BEL-VIALAR
  • Bertrand BENAZERAF
  Technical staff
  • Guillaume ALLIO
  • François MEDEVIELLE
  • Mélanie ROUSSAT


Our aim is to understand how the cell cycle affects cell fate decisions in organ development and homeostasis using as a paradigm the developing nervous system. Deciphering the core machinery of cell cycle has been mostly the focus of cell biologists, while, developmental biologists identified the signaling pathways and transcriptional programs controlling cell fate choices. The interplay between these two fundamental aspects of biology remained largely unexplored. The goal of our project is to implement molecular analyses with advanced technique in time-lapse imaging to elucidate how changes in cell cycle features switch a proliferating neural progenitor into a differentiating neuron.


Function of a cell cycle regulator, the CDC25B phosphatase, in Vertebrate neurogenesis

Role of cell cycle in cell fate decision during organogenesis: Insight into the developing nervous system using single cell high resolution time lapse imaging

Multi-tissue analysis of axis elongation in vertebrate embryo

The CDC25B phosphatase shortens the G2 phase of neural progenitors and promotes efficient neuron production

The proneural NeuroG2 drives cell cycle exit of neuronal precursors by specifically repressing a subset of cyclins acting at the G1 and S phases of the cell cycle


  • Bonnet F, Molina A, Roussat M, Azais M, Bel-Vialar S, Gautrais J, Pituello F, Agius E.
    Neurogenic decisions require a cell cycle independent function of the CDC25B phosphatase.
    2018 Jul
  • Lacomme M, Medevielle F, Bourbon HM, Thierion E, Kleinjan DJ, Roussat M, Pituello F, Bel-Vialar S..
    A long range distal enhancer controls temporal fine-tuning of PAX6 expression in neuronal precursors.
    Dev Biol.
    2018 Apr
  • Angie Molina, Fabienne Pituello.
    Playing with the cell cycle to build the spinal cord
    Developmental Biology
    2017 Dec review
  • Bertrand Bénazéraf*, Mathias Beaupeux, Martin Tchernookov, Allison Wallingford, Tasha Salisbury, Amelia Shirtz, Andrew Shirtz, David Huss, Olivier Pourquié*, Paul François*, Rusty Lansford*.
    Multiscale quantification of tissue behavior during amniote embryo axis elongation
    2017 Sep * co-coresponding authors, in press
  • 2015 Jan AGIUS, E., BEL-VIALAR, S., BONNET, F., PITUELLO, F. (2015). Cell cycle and cell fate in the developing nervous system: the role of CDC25B phosphatase. Cell Tissue Res 359, 201-13.

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