REMEMBeR : Revealing Memory Mechanisms of the Brain

Claire RAMPON


DR CNRS
05 61 55 75 75

Team members

  Researcher
  • Lionel DAHAN
  • Cedrick FLORIAN
  • Bernard FRANCES
  • Bruno GUIARD
  • Lionel MOULEDOUS
  • Pascal ROULLET
  • Laure VERRET
  Technical staff
  • Camille LEJARDS
  • Sébastien LOPEZ
  • Stéphane PECH
  Postdoc
  • Stella MANTA
  PhD
  • Trinovita ANDRAINI
  • Vanessa CATTAUD
  • François LABASTE
  • Benjamin PORTAL
  • Khaoula REKIK
  • Christophe REY

Presentation

Our research addresses the fundamental question of how enduring memories are formed in the brain. We are studying more specifically mechanisms of cerebral plasticity related to spatial and episodic memory in normal mice and in mouse models of memory dysfunctions or pathologies (Alzheimer’s disease, mood disorders, post-traumatic stress disorder). Our work focuses on learning-induced plasticity processes at different levels from the activity of neuronal networks (cerebral oscillations, synaptic plasticity, inhibitory networks), to cells (neurogenesis, morphology of neurons or glial cells, interactions between neurons and glia), neurobiological issues (protein or gene expression, release of neurotransmitters, role of mitochondria) to finally work at the molecular level (epigenetic regulations, role of transcriptional factors).

Projets

Hippocampus dysfunction and Alzheimer’s Disease

Impact of metabolic disorders on mood and memory impairments

Memory reconsolidation and PTSD treatment

Neuropeptides and memory

Adult neurogenesis and memory

Synaptic plasticities induced by learning

Transcriptional control of memory consolidation

Publications

  • Rekik K, Faria Da Silva R, Colom M, Pacifico S, Zaveri NT, Calo' G, Rampon C, Frances B, Mouledous L.
    Activation of nociceptin/orphanin FQ receptors inhibits contextual fear memory reconsolidation
    Neuropharmacology. 2017 Oct;125:39-49. doi: 10.1016
    2017 Jul
  • Richetin K, Petsophonsakul P, Roybon L, Guiard BP, Rampon C.
    Differential alteration of hippocampal function and plasticity in females and males of the APPxPS1 mouse model of Alzheimer’s disease
    Neurobiol Aging. 2017 Sep;57:220-231. doi: 10.1016
    2017 Jun
  • Richetin K, Moulis M, Millet A, Arràzola MS, Andraini T, Hua J, Davezac N, Roybon L, Belenguer P, Miquel MC, Rampon C.
    Amplifying mitochondrial function rescues adult neurogenesis in a mouse model of Alzheimer’s disease
    Neurobiol Dis. 2017 Jun;102:113-124. doi: 10.1016
    2017 Jun
  • Rekik K, Francés B, Valet P, Dray C, Florian C.
    Cognitive deficit in hippocampal-dependent tasks in Werner syndrome mouse model
    Behav Brain Res. 2017 Jan 21;323:68-77
    2017 Jan
  • Petsophonsakul P, Richetin K, Andraini T, Roybon L, Rampon C.
    Memory formation orchestrates the wiring of adult-born hippocampal neurons into brain circuits
    Brain Struct Funct. 2017 Aug;222(6):2585-2601. doi: 10.1007
    2017 Jan

View all publications

Funding

                 

Institut Universitaire de France

 

 

Alumni

  • Petnoi Petsophonsakul (PhD in 2017), currently employed by a private company in England
  • Hélène VILLAIN (PhD in 2016)
  • Charlotte BEZZINA (PhD in 2015), currently in Psychology school in Toulouse
  • Jessica REMAUD (PhD in 2014), currently "Responsable R&D " at AgreenCulture
  • Kevin RICHETIN (PhD in 2014), currently postdoc at UNIL Lausanne
  • Nicolas MASSALY (PhD in 2012), currently postdoc at Washington University in St Louis, MI
  • Clémence LECLERC (PhD in 2012), currently employed by a private company
  • Alice KREZYMON (PhD in 2012), currently teacher in Irvine, California
  • Timothé ESCUDE (PhD in 2012) currently Med School student in Toulouse
  • Johnatan CECCOM (PhD in 2011), currently at School of Pharmacy in Toulouse
  • Stéphanie TROUCHE (PhD in 2009) currently Investigator Scientist in Oxford (MRC, D Dupret)
  • Alexandre BETOURNE (PhD in 2008), currently Chief Medical Officer at Above and Beyond (Atlanta, GA)

Université Paul Sabatier
118 Route de Narbonne

31062 TOULOUSE Cedex
France

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