REMEMBeR : Revealing Memory Mechanisms of the Brain


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Team members

  • Lionel DAHAN
  • Cedrick FLORIAN
  • Bernard FRANCES
  • Bruno GUIARD
  • Lionel MOULEDOUS
  • Pascal ROULLET
  • Laure VERRET
  Technical staff
  • Camille LEJARDS
  • Sébastien LOPEZ
  • Stéphane PECH
  • Stella MANTA
  • Trinovita ANDRAINI
  • Vanessa CATTAUD
  • François LABASTE
  • Benjamin PORTAL
  • Khaoula REKIK
  • Christophe REY


Our research addresses the fundamental question of how enduring memories are formed in the brain. We are studying more specifically mechanisms of cerebral plasticity related to spatial and episodic memory in normal mice and in mouse models of memory dysfunctions or pathologies (Alzheimer’s disease, mood disorders, post-traumatic stress disorder). Our work focuses on learning-induced plasticity processes at different levels from the activity of neuronal networks (cerebral oscillations, synaptic plasticity, inhibitory networks), to cells (neurogenesis, morphology of neurons or glial cells, interactions between neurons and glia), neurobiological issues (protein or gene expression, release of neurotransmitters, role of mitochondria) to finally work at the molecular level (epigenetic regulations, role of transcriptional factors).


Hippocampus dysfunction and Alzheimer’s Disease

Impact of metabolic disorders on mood and memory impairments

Memory reconsolidation and PTSD treatment

Neuropeptides and memory

Adult neurogenesis and memory

Synaptic plasticities induced by learning

Transcriptional control of memory consolidation


  • Rekik K, Francés B, Valet P, Dray C, Florian C.
    Cognitive deficit in hippocampal-dependent tasks in Werner syndrome mouse model
    Behav Brain Res. 2017 Jan 21;323:68-77
    2017 Jan
  • Petsophonsakul P, Richetin K, Andraini T, Roybon L, Rampon C.
    Memory formation orchestrates the wiring of adult-born hippocampal neurons into brain circuits
    Brain Struct Funct. 2017 Jan 6
    2017 Jan
  • Pham TH, Mendez-David I, Defaix C, Guiard BP, Tritschler L, David DJ, Gardier AM.
    Ketamine treatment involves medial prefrontal cortex serotonin to induce a rapid antidepressant-like activity in BALB/cJ mice
    Neuropharmacology. 2017 Jan;112(Pt A):198-209
    2016 Dec
  • Besson M, Guiducci S, Granon S, Guilloux JP, Guiard B, Repérant C, Faure P, Pons S, Cannazza G, Zoli M, Gardier AM, Maskos U.
    Alterations in alpha5* nicotinic acetylcholine receptors result in midbrain- and hippocampus-dependent behavioural and neural impairments
    Psychopharmacology (Berl). 2016 Sep;233(18):3297-314
    2016 Sep
  • Villain H, Florian C, Roullet P.
    HDAC inhibition promotes both initial consolidation and reconsolidation of spatial memory in mice
    Sci Rep. 2016 Jun 7;6:27015
    2016 Jun

View all publications



Institut Universitaire de France




  • Petnoi Petsophonsakul (PhD in 2017), currently employed by a private company in England
  • Hélène VILLAIN (PhD in 2016)
  • Charlotte BEZZINA (PhD in 2015), currently in Psychology school in Toulouse
  • Jessica REMAUD (PhD in 2014), currently "Responsable R&D " at AgreenCulture
  • Kevin RICHETIN (PhD in 2014), currently postdoc at UNIL Lausanne
  • Nicolas MASSALY (PhD in 2012), currently postdoc at Washington University in St Louis, MI
  • Clémence LECLERC (PhD in 2012), currently employed by a private company
  • Alice KREZYMON (PhD in 2012), currently teacher in Irvine, California
  • Timothé ESCUDE (PhD in 2012) currently Med School student in Toulouse
  • Johnatan CECCOM (PhD in 2011), currently at School of Pharmacy in Toulouse
  • Stéphanie TROUCHE (PhD in 2009) currently Investigator Scientist in Oxford (MRC, D Dupret)
  • Alexandre BETOURNE (PhD in 2008), currently Chief Medical Officer at Above and Beyond (Atlanta, GA)

Université Paul Sabatier
118 Route de Narbonne

31062 TOULOUSE Cedex

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