REMEMBeR : Revealing Memory Mechanisms of the Brain
Directrice de Recherches - CNRS 05 61 55 75 75
Researcher Technical staff
- Camille LEJARDS
- Sébastien LOPEZ
- Stéphane PECH
- Sébastien BULLICH
- Vanessa CATTAUD
- Basile COUTENS
- François LABASTE
- Benjamin PORTAL
- Christophe REY
- Fares SAYEGH
- Anna SZABO
Our research addresses the fundamental question of how enduring memories are formed in the brain. We are studying more specifically mechanisms of cerebral plasticity related to spatial and episodic memory in normal mice and in mouse models of memory dysfunctions or pathologies (Alzheimer’s disease, mood disorders, post-traumatic stress disorder). Our work focuses on learning-induced plasticity processes at different levels from the activity of neuronal networks (cerebral oscillations, synaptic plasticity, inhibitory networks), to cells (neurogenesis, morphology of neurons or glial cells, interactions between neurons and glia), neurobiological issues (protein or gene expression, release of neurotransmitters, role of mitochondria) to finally work at the molecular level (epigenetic regulations, role of transcriptional factors).
Our team is a member of:
Hippocampus dysfunction and Alzheimer’s Disease
Impact of metabolic disorders on mood and memory impairments
Memory reconsolidation and PTSD treatment
Adult neurogenesis and memory
Synaptic plasticities induced by learning
Transcriptional control of memory consolidation
- Chatterjee S, Cassel R, Schneider-Anthony A, Merienne K, Cosquer B, Tzeplaeff L, Halder Sinha S, Kumar M, Chaturbedy P, Eswaramoorthy M, Le Gras S, Keime C, Bousiges O, Dutar P, Petsophonsakul P, Rampon C, Cassel JC, Buée L, Blum D, Kundu TK, Boutillier AL.
Reinstating plasticity and memory in a tauopathy mouse model with an acetyltransferase activator
EMBO Mol Med. 2018, in press
- Cattaud V, Bezzina C, Rey CC, Lejards C, Dahan L, Verret L.
Early disruption of parvalbumin expression and perineuronal nets in the hippocampus of the Tg2576 mouse model of Alzheimer's disease can be rescued by enriched environment.
Neurobiol Aging. 2018, in press
- Arrázola MS, Andraini T, Szelechowski M, Mouledous L, Arnauné-Pelloquin L, Davezac N, Belenguer P, Rampon C, Miquel MC.
Mitochondria in developmental and adult neurogenesis
Neurotox Res. 2018, in press
- Peyron C, Rampon C, Petit JM, Luppi PH.
Sub-regions of the dorsal raphe nucleus receive different inputs from the brainstem
Sleep Med. 2018 Sep;49:53-63. doi: 10.1016
- Martinez-Losa M.*, Tracy T.E.*, Ma K.*, Verret L., Clemente-Perez A., Khan A.S., Cobos I., Ho K., Gan L., Mucke L., Alvarez-Dolado M., Palop J.J.
Nav1.1-Overexpressing Interneuron Transplants Restore Brain Rhythms and Cognition in a Mouse Model of Alzheimer’s Disease
Neuron. 2018 Apr 4;98(1):75-89.e5. doi: 10.1016
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- Trinovita ANDRAINI (PhD in 2017), currently associate professor at Medical University of Indonesia, Jakarta
- Khaoula REKIK (PhD in 2017)
- Petnoi PETSOPHONSAKUL (PhD in 2017), currently employed by a private company in England
- Hélène VILLAIN (PhD in 2016)
- Charlotte BEZZINA (PhD in 2015), currently in Psychology school in Toulouse, France
- Jessica REMAUD (PhD in 2014), currently "Responsable R&D " at AgreenCulture, France
- Kevin RICHETIN (PhD in 2014), currently postdoc at UNIL Lausanne, Switzerland
- Nicolas MASSALY (PhD in 2012), currently postdoc at Washington University in St Louis, MI, USA
- Clémence LECLERC (PhD in 2012), currently employed by a private company
- Alice KREZYMON (PhD in 2012), currently teacher in Irvine, California, USA
- Timothé ESCUDE (PhD in 2012) currently Med School student in Toulouse, France
- Johnatan CECCOM (PhD in 2011), currently at School of Pharmacy in Toulouse, France
- Stéphanie TROUCHE (PhD in 2009) currently CNRS Researcher at IGF Montpellier, France
- Alexandre BETOURNE (PhD in 2008), currently Chief Medical Officer at Above and Beyond, Atlanta, GA, USA