REMEMBeR : Revealing Memory Mechanisms of the Brain


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Team members

  Researcher  Technical staff
  • Camille LEJARDS
  • Sébastien LOPEZ
  • Stéphane PECH
  • Stella MANTA
  • Vanessa CATTAUD
  • François LABASTE
  • Benjamin PORTAL
  • Christophe REY


Our research addresses the fundamental question of how enduring memories are formed in the brain. We are studying more specifically mechanisms of cerebral plasticity related to spatial and episodic memory in normal mice and in mouse models of memory dysfunctions or pathologies (Alzheimer’s disease, mood disorders, post-traumatic stress disorder). Our work focuses on learning-induced plasticity processes at different levels from the activity of neuronal networks (cerebral oscillations, synaptic plasticity, inhibitory networks), to cells (neurogenesis, morphology of neurons or glial cells, interactions between neurons and glia), neurobiological issues (protein or gene expression, release of neurotransmitters, role of mitochondria) to finally work at the molecular level (epigenetic regulations, role of transcriptional factors).


Hippocampus dysfunction and Alzheimer’s Disease

Impact of metabolic disorders on mood and memory impairments

Memory reconsolidation and PTSD treatment

Neuropeptides and memory

Adult neurogenesis and memory

Synaptic plasticities induced by learning

Transcriptional control of memory consolidation


  • Martinez-Losa M, Tracy TE, Ma K, Verret L, Clemente-Perez A, Khan AS, Cobos I, Ho K, Gan L, Mucke L, Alvarez-Dolado M, Palop JJ.
    Nav1.1-Overexpressing Interneuron Transplants Restore Brain Rhythms and Cognition in a Mouse Model of Alzheimer's Disease
    Neuron. 2018 Mar 15. doi: 10.1016/j.neuron.2018.02.029
    2018 Mar
  • Bétourné A, Szelechowski M, Thouard A, Abrial E, Jean A, Zaidi F, Foret C, Bonnaud EM, Charlier CM, Suberbielle E, Malnou CE, Granon S, Rampon C, Gonzalez-Dunia D..
    Hippocampal expression of a virus-derived protein impairs memory in mice.
    Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):1611-1616. doi: 10.1073
    2018 Feb
  • Villain H, Benkahoul A, Birmes P, Ferry B, Roullet P..
    Influence of early stress on memory reconsolidation: Implications for post-traumatic stress disorder treatment.
    PLoS One. 2018 Jan 19;13(1):e0191563. doi: 10.1371
    2018 Jan
  • Rekik K, Faria Da Silva R, Colom M, Pacifico S, Zaveri NT, Calo' G, Rampon C, Frances B, Mouledous L.
    Activation of nociceptin/orphanin FQ receptors inhibits contextual fear memory reconsolidation
    Neuropharmacology. 2017 Oct;125:39-49. doi: 10.1016
    2017 Jul
  • Richetin K, Petsophonsakul P, Roybon L, Guiard BP, Rampon C.
    Differential alteration of hippocampal function and plasticity in females and males of the APPxPS1 mouse model of Alzheimer’s disease
    Neurobiol Aging. 2017 Sep;57:220-231. doi: 10.1016
    2017 Jun

View all publications



Institut Universitaire de France




  • Petnoi Petsophonsakul (PhD in 2017), currently employed by a private company in England
  • Hélène VILLAIN (PhD in 2016)
  • Charlotte BEZZINA (PhD in 2015), currently in Psychology school in Toulouse
  • Jessica REMAUD (PhD in 2014), currently "Responsable R&D " at AgreenCulture
  • Kevin RICHETIN (PhD in 2014), currently postdoc at UNIL Lausanne
  • Nicolas MASSALY (PhD in 2012), currently postdoc at Washington University in St Louis, MI
  • Clémence LECLERC (PhD in 2012), currently employed by a private company
  • Alice KREZYMON (PhD in 2012), currently teacher in Irvine, California
  • Timothé ESCUDE (PhD in 2012) currently Med School student in Toulouse
  • Johnatan CECCOM (PhD in 2011), currently at School of Pharmacy in Toulouse
  • Stéphanie TROUCHE (PhD in 2009) currently Investigator Scientist in Oxford (MRC, D Dupret)
  • Alexandre BETOURNE (PhD in 2008), currently Chief Medical Officer at Above and Beyond (Atlanta, GA)

Université Paul Sabatier
118 Route de Narbonne

31062 TOULOUSE Cedex

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