Spatio-temporal control of cell division


Yannick GACHET

05 61 55 81 13

05 61 55 81 13

Team members

  Technical staff
  • Céline REYES
  • Nawel FELLOUAH
  • Tong LI


The accurate segregation of sister chromatids to daughter cells requires both the bipolar attachment of centromeres to the mitotic spindle and the correct positioning of the spindle with respect to the axis of cytokinesis. Cytokinesis always takes place perpendicularly to the axis of the spindle once chromosomes are segregated. These different events are coordinated in space and time in order to prevent the formation of aneuploid cells, a phenotype frequently observed in cancer and genetic diseases. The precise mechanisms leading to aneuploidy is unknown but is likely to be caused by either a defect in chromosome segregation, a defect in spindle positioning, a defect in cytokinesis or a combination of these defects. Although it is clearly established that faithful kinetochore/microtubule attachment is essential to prevent aneuploidy, several questions remain, such as:

What are the molecular mechanisms, which correct chromosome mis-attachment and how mis-attachment correction is coordinated with cytokinesis?

Using a multidisciplinary approach including genetic, video-microscopy and mathematical modeling techniques the aim of our lab is to identify the key players controlling chromosome segregation. We believe that our study performed in fission yeast will unveil new, basic and conserved mechanisms responsible for aneuploidy.


Modeling chromosome segregation and cell division

Identification of the mechanisms controlling aneuploidy


  • Li T, Mary H, Grosjean M, Fouchard J, Cabello S, Reyes C, Tournier S, Gachet Y.
    MAARS: a novel high-content acquisition software for the analysis of mitotic defects in fission yeast
    Molecular Biology of the Cell
    2017 Jul
  • Cabello S, Gachet Y, Tournier S..
    Cutting edge science: Laser surgery illuminates viscoelasticity of merotelic kinetochores
    J Cell Biol. Mar 28;212(7):747-9.
    2016 Mar
  • Gachet Y, Reyes C, Tournier S..
    Aurora B kinase controls the separation of centromeric and telomeric heterochromatin
    Mol Cell Oncol.
    2015 Nov
  • Mary H, Fouchard J, Gay G, Reyes C, Gauthier T, Gruget C, Pécréaux J, Tournier S , Gachet Y .
    Fission yeast kinesin-8 controls chromosome congression independently of oscillations.
    J.CellSci. Oct 15;128(20):3720-30
    2015 Oct
  • 2015 Jan Le Bourg E, Gauthier T, Colinet H. Feeding on frozen live yeast has some deleterious effects in Drosophila melanogaster. Exp Gerontol. 2015; 7;69:202-210.

View all publications




Université Paul Sabatier
118 Route de Narbonne

31062 TOULOUSE Cedex

Annuaire général