Transcriptional co-activators in cell differentiation and in cancer

Laurence VANDEL


DR CNRS
05 61 55 83 83

Team members

  Postdoc
  • Aurélie QUILLIEN
  PhD
  • Sarah DIOUF

Presentation

Our main goal is to understand the role and the mechanisms of action of histone modifying enzymes that regulate transcription dependent on transcription factors controlling cell fate. We are more focusing on the Protein arginine methyltransferase family (PRMTs) and the acetyltransferases CBP (CREB Binding Protein) and p300 in cell differentiation and in cancer. Using gain and loss of function approaches we want to 1) identify and compare the role(s) of CBP and p300 at genome wide level in human primary myoblasts during differentiation 2) analyse the gene networks regulated by two PRMTs in human primary endothelial cells as well as in angiogenesis in zebrafish embryo.

Projets

PRMTs in physiological and pathological angiogenesis

Role(s) of CBP and p300 and of their methylation in myogenesis

Publications

  • Batut J, Duboé C, Vandel L. .
    Expression patterns of CREB Binding Protein (CREBBP) and its methylated species during zebrafish development
    IJDB
    2015 Aug
  • Ceschin DG, Walia M, Wenk SS, Duboé C, Gaudon C, Xiao Y, Fauquier L, Sankar M, Vandel L*, Gronemeyer H*.
    Methylation specifies distinct estrogen-induced binding site repertoires of CBP to chromatin.
    Genes Dev.
    2011 Jun 25(11):1132-46
  • Batut J, Duboé C, Vandel L.
    The methyltransferases PRMT4/CARM1 and PRMT5 control differentially myogenesis in zebrafish
    PLoS One
    2011 Jan 6(10):e25427

Funding

               

Université Paul Sabatier
118 Route de Narbonne

31062 TOULOUSE Cedex
France

Annuaire général