Transcriptional co-activators in cell differentiation and in cancer
Our main goal is to understand the role and the mechanisms of action of histone modifying enzymes that regulate transcription dependent on transcription factors controlling cell fate. We are more focusing on the Protein arginine methyltransferase family (PRMTs) and the acetyltransferases CBP (CREB Binding Protein) and p300 in cell differentiation and in cancer. Using gain and loss of function approaches we want to 1) identify and compare the role(s) of CBP and p300 at genome wide level in human primary myoblasts during differentiation 2) analyse the gene networks regulated by two PRMTs in human primary endothelial cells as well as in angiogenesis in zebrafish embryo.
PRMTs in physiological and pathological angiogenesis
Role(s) of CBP and p300 and of their methylation in myogenesis
- Batut J, Duboé C, Vandel L. .
Expression patterns of CREB Binding Protein (CREBBP) and its methylated species during zebrafish development
- Ceschin DG, Walia M, Wenk SS, Duboé C, Gaudon C, Xiao Y, Fauquier L, Sankar M, Vandel L*, Gronemeyer H*.
Methylation specifies distinct estrogen-induced binding site repertoires of CBP to chromatin.
2011 Jun 25(11):1132-46
- Batut J, Duboé C, Vandel L.
The methyltransferases PRMT4/CARM1 and PRMT5 control differentially myogenesis in zebrafish
2011 Jan 6(10):e25427