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  • Rampon
  • Presentation

    Associate Professor, Université Paul Sabatier, IUF Junior Member 2016-2021

    Remember Team

    Research axis :
    Memory / Alzheimer / Cognition

    Research topics :
    Inhibitory function / Brain oscillations / Neuronal plasticity / Cognitive deficits

    Techniques :
    EEG / Behavioral assays / Immunohistochemistry

    Project summary :

    Today, the mechanisms at the origin of the progressive loss of cognitive functions associated with Alzheimer's disease (AD) remain largely unknown. Our recent studies have shown a dysfunction of inhibitory parvalbumin (PV) interneurons in transgenic mouse models of the disease, as well as in AD patients. PV interneurons coordinate neuronal activity in the local network and throughout the brain, thus their activity is necessary for cognitive functions. In this context, the aim of my research project is to identify functional changes of PV interneurons in mouse models of AD which may induce memory deficits, and to establish new restoration strategies for memory functions in AD.


    PhD students :

    • Vanessa Cattaud « Interneuronal dysfunction and cognitive deficits in mouse model of AD », Vaincre Alzheimer PhD Fellow, 2016-2019 (co-dir L. Dahan)
    • Christophe Rey « Social memory impairments and interneuronal dysfunction in Alzheimer’s disease », PhD Fellow, 2017-2020 (co-dir C. Rampon)








    Lionel Dahan & Vanessa Cattaud

    Christophe Rey


    • Vivien Chevaleyre, Centre de Psychiatrie et Neurosciences, Paris, Fr
    • Jorge J. Palop, Gladstone Institute of Neurological Disease, UC San Francisco, USA

    Recent publications:

    • Broestl L., Worden K., Moreno A.J., Davis E.J., Wang D., Garay B., Singh T., Verret L., Palop J.J., Dubal D.B. Ovarian cycle stages modulate Alzheimer-related cognitive and brain network alterations in female mice. (2018) eNeuro Dec 14;5(6) Link
    • Cattaud V., Bezzina C., Rey C.C., Lejards C., Dahan L., Verret L. Early disruption of parvalbumin expression and perineuronal nets in the hippocampus of the Tg2576 mouse model of Alzheimer’s disease can be rescued by enriched environment. (2018) Neurobiol Aging 72:147-158. Link
    • Martinez-Losa M.*, Tracy T.E.*, Ma K.*, Verret L., Clemente-Perez A., Khan A.S., Cobos I., Ho K., Gan L., Mucke L., Alvarez-Dolado M.*, Palop J.J.* Nav1.1-Overexpressing Interneuron Transplants Restore Brain Rhythms and Cognition in a Mouse Model of Alzheimer’s Disease. (2018) Neuron 98:1-15. Link
    • Zerwas M.*, Trouche S.*, Richetin K., Escudé T., Halley H., Gérardy-Schahn R., Verret L., Rampon C. Environmental enrichment rescues memory in mice deficient for the polysialytransferase ST8SiaIV. (2016) Brain, Structure, Function 221(3):1591-1605. Link
    • Morris M., Sanchez P.E., Verret L., Beagle A.J., Guo W., Dubal D.B., Ranasinghe K.G., Koyama A., Ho K., Yu G.-Q., Vossel K.A., Mucke L. Neural network dysfunction in α-synuclein transgenic mice and Humans with Lewy body dementia. (2015) Annals of Clinical and Translational Neurology 2(11):1012-1028. Link
    • Bezzina C., Verret L., Halley H., Dahan L.*, Rampon C.* Environmental enrichment does not influence hypersynchronous network activity in the Tg2576 mouse model of Alzheimer’s disease. (2015) Frontiers in Aging Neuroscience 7:178. Link
    • Bezzina C., Verret L., Juan C., Remaud J., Halley H., Rampon C.*, Dahan L.* Early onset of aberrant hypersynchronous network activity and expression of marker of chronic seizures in the Tg2576 mouse model of Alzheimer's disease. (2015) PLoS ONE 10(3):e0119910. Link
    • Krezymon A., Richetin K., Halley H., Roybon L., Lassalle J.M., Frances B., Verret L.*, Rampon C.* Modifications of hippocampal circuits and early disruption of adult neurogenesis in the tg2576 mouse model of Alzheimer's disease. (2013) PLoS ONE 8(9):e76497. Link
    • Heng M.Y., Lin S.T., Verret L., Huang Y., Kamiya S., Padiath Q.S., Tong Y., Palop J.J., Huang E.J., Ptáček L.J., Fu Y.H. Lamin B1, a novel myelin regulator, mediates cell-autonomous neuropathology in a murine ADLD model. (2013) J Clin Invest 123(6):2719-29 (Featured on the cover of the June 3 issue) Link
    • Verret L., Krezymon A., Halley H., Trouche S., Zerwas M., Lazouret M., Lassalle J.M., Rampon C. Transient enriched housing before amyloidosis onset sustains cognitive improvement in Tg2576 mice. (2013) Neurobiol Aging 3:211-25. Link
    • Verret L. [Repairing rhythms in the brain of Alzheimer’s mouse models.] (2012) Med Sci (Paris) 28(12) 1038-41. Link
    • Sanchez P.E., Zhu L., Verret L., Vossel K.A., Orr A.G., Cirrito J.R., Devidze N., Yu G.Q., Palop J.J, Mucke L. Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in mouse model of Alzheimer’s disease. (2012) Proc Natl Acad Sci USA 109(42):E2895-903 Link
    • Verret L., Mann E.O., Hang G.B., Barth A., Cobos I., Ho K., Devidze N., Masliah E., Kreitzer A.C., Mody I., Mucke L., Palop J.J. Inhibitory interneuron deficit links abnormal network activity and cognitive dysfunction in Alzheimer model. (2012) Cell 149: 708-21. (Featured on the cover of the April 27 issue) Link
    • Faure A., Verret L., Bozon B., El Tannir El Tayara N., Kober F., Dhenain M., Rampon C., Delatour B. Impaired neurogenesis, neuronal loss, and brain functional deficits in the APPxPS1-Ki mouse model of Alzheimer’s disease. (2011) Neurobiol Aging 32(3) 407-418. Link
    • Harris J.A., Devidze N., Verret L., Ho K., Halabisky B., Thwin M.T., Kim D., Hamto P., Lo I., Yu G.Q., Palop J.J., Masliah E., Mucke L. Transsynaptic progression of amyloid-β-induced neuronal dysfunction within the entorhinal-hippocampal network. (2010) Neuron 68(3) 428-441. Link
    • Goodman T.*, Trouche S.*, Massou I., Verret L., Zerwas M., Roullet P., Rampon C. Young hippocampal neurons are critical for recent and remote spatial memory in adult mice. (2010) Neuroscience 171(3):769-778. Link
    • Lassalle J.M., Halley H., Daumas S., Verret L., Frances B. The influence of the genetic background on behavioral performances of Tg2576 mice. (2008) Behav Brain Res 191(1) 104-110. Link
    • Verret L., Trouche S., Zerwas M., Rampon C. Hippocampal neurogenesis during normal and pathological aging. (2007) Psychoneuroendocrinology 32(8) S26-S30. Link
    • Verret L.*, Jankowsky J.L.*,  Xu G.M., Borchelt D.R., Rampon C. Alzheimer’s-type amyloidosis in mice impairs survival of newborn neurons derived from adult hippocampal neurogenesis. (2007) J Neurosci 27(25) 6771-6780. Link

    Université Paul Sabatier
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    31062 TOULOUSE Cedex

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