Controlling mechanism of rotational movement during collective cell migration

Intervenants

  • Xiaobo WANG
  • Valérie CADAMURO
  • Jiaying LIU

Currently, chemotaxis is a major concept to explain the polarity of collectively migratory cell group and thus the choice and difference of leader cells from other cells. However, this concept of chemotaxis-deciding leader cell can’t explain an interesting observation from both collective border cell migration in Drosophila ovary and collective cancer cell migration in wound healing assay: cells can change their relative position and thus leaders can be replaced by others, through rotation or tumbling movement. Here, we are trying to elucidate the controlling mechanism of this rotation behavior using both ex vivo drosophila and in vitro cell models. 

Funding

Other funding : ATIP-Avenir

Université Paul Sabatier
118 Route de Narbonne

31062 TOULOUSE Cedex
France

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