Impact of the universally conserved ribonucleases from the β-CASP family on archaeal RNA metabolism

This project aims at understanding the relevance of the interplay of β-CASP RNases and SKi2 RNA helicases in RNA processing pathways by using omics and genetics approaches. Our goal is to identify their protein networks and RNA targets, decipher their organization in macromolecular complexes and determine their respective ribonucleolytic and RNA helicase enzymatic activities. Our study models are Thermococcales archaea.

Collaborators

G. Fichant - CBI, Toulouse, France

D. Flament -  BEEP, Brest, France

C. Gaspin - MIAT, INRAE, Auzeville-Tolosan, France

M. Jebbar - BEEP, Brest, France

D. Grohmann - Universitat Regensburg , Allemagne

Funding

GDR Archées