Specific mechanisms of pre-ribosomal RNA processing in human cells

Intervenants

  • Pierre-Emmanuel Gleizes
  • Franck Delavoie
  • Charlotte Guette
  • Sarah Le Page
  • Nathalie Montel-Lehry
  • Marie-Françoise O'donohue

Specific mechanisms of pre-ribosomal RNA processing in human cells

Project leaders: Marie-Françoise O'Donohue, Pierre-Emmanuel Gleizes

Our investigation of human pre-rRNA processing has revealed mechanisms specific to mammalian cells when compared to the well-studied yeast S. cerevisiae, as visualized by the presence of distinct intermediate RNAs and the involvement of additional enzymes. Hence, we recently showed the unexpected requirement of 3'-5' exonucleases in the maturation of the 18S rRNA precursors. We are currently being characterizing the enzymes involved in this process.

Funding

       

Université Paul Sabatier
118 Route de Narbonne

31062 TOULOUSE Cedex
France


05 61 33 58 00

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