Mécanismes de la maturation des ARN ribosomiques chez l'homme

Intervenants

  • Marie-Françoise O'DONOHUE
  • Nathalie MONTEL-LEHRY

Our investigation of human pre-rRNA processing has revealed mechanisms specific to mammalian cells when compared to the well-studied yeast S. cerevisiae, as visualized by the presence of distinct intermediate RNAs and the involvement of additional enzymes. Hence, we recently showed the unexpected requirement of 3'-5' exonucleases in the maturation of the 18S rRNA precursors. We are currently being characterizing the enzymes involved in this process.

Financements

     

Université Paul Sabatier
118 Route de Narbonne

31062 TOULOUSE Cedex
France

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