Agenda

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Séminaires CBI de la semaine du 05-11-2018 au 11-11-2018

Lundi 05 Novembre

Mardi 06 Novembre

Mercredi 07 Novembre

Jeudi 08 Novembre

Vendredi 09 Novembre

CORTI Olga, Institut Cerveau & Moëlle Epinière, UPMC, Paris
CBI séminaire public
Titre : The PINK1/Parkin pathway, a complex route to Parkinson’s disease
11:00
IBCG | Salle Conférence (100 pers.)

Mitochondrial dysfunction has long been suspected to play a role in the pathogenesis of Parkinson’s disease. This hypothesis has received strong support in recent years, with the discovery of gene responsible for familial Parkinson’s disease playing roles in mitochondrial maintenance. The products of the PINK1 and PARK2 (Parkin) genes cooperate in sensing mitochondrial dysfunction and linking it to the activation of protective mitochondrial quality control programs, including mitophagy. Despite the remarkable advances in our understanding of the molecular mechanisms by which PINK1 and Parkin promote mitophagy, little is known about how their dysfunction leads to neuronal degeneration. I will present recent efforts from our laboratory to understand how dysfunction of the PINK1/Parkin pathway impact impairs the ability of neurons to respond to mitochondrial stress, focusing on both cell autonomous and non-autonomous mechanisms. I will also present a new mechanism by which PINK1 and Parkin preserve the quality of mitochondria.

Jean-Claude DREHER, Neuroeconomics laboratory, Institut des Sciences Cognitive Marc Jeannerod, Bron, France
CBI séminaire public
Titre : Neural mechanism engaged in individual and group decision making
14:00
IBCG | Salle Conférence (100 pers.)

Samedi 10 Novembre

Dimanche 11 Novembre

Université Paul Sabatier
118 Route de Narbonne

31062 TOULOUSE Cedex
France


05 61 33 58 00

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