Nicolas Massaly (WUSM, Saint Louis, MO)Autre séminaire
Titre : Séminaire Nicolas Massaly
16:30* Salle Conférence Vandel
Pain-induced Negative Affect , a role for the dynorphin kappa system
The nucleus accumbens (NAc) shell, which integrates both the aversive and rewarding valence of stimuli, exhibits allostatic changes in the presence of pain. In discrete regions of this structure, activation of the kappa opioid receptor (KOR), either by dynorphin, its endogenous agonist, or pharmacological ligands, acutely decreases the reinforcing properties of rewards and induces dysphoria and aversive behaviors. Using a wide range of complementary techniques including pharmacology, optogenetics, chemogenetics, physiology, biochemistry and in vivo positron emission tomography (PET) imaging, we demonstrate that in vivo recruitment of NAc shell dynorphin neurons, acting through KOR, is both necessary and sufficient to drive pain-induced negative affect.