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Séminaires de la semaine du 22-01-2018 au 28-01-2018

Lundi 22 Janvier

Séminaire axe GD
Titre : A family of negative transcription elongation factors regulates defense response genes and protects the genome of A. thaliana from transcriptional interferences
* Salle Conférence IBCG

Mardi 23 Janvier

Maylis Gallois (Payre group)
Séminaire axe CDD
Titre : Réunion interne axe CDD
* Salle Conférence Vandel

Temporal control of cell remodeling

Part 1 : A new role for Pri peptides in the temporal repression of cuticle genes

Part 2 : Temporal control of epidermal differentiation during post-embryonic development

Mercredi 24 Janvier

Séminaire axe NS
Titre : Séminaire Axe Neuro
* Salle Conférence Vandel
   (Institute of Neurodegenerative Diseases (IMN), CNRS UMR5293, Bordeaux)
 nous parlera de: « 
L-DOPA: Old Médecine, New Concepts».

Summary: The antiparkinsonian agent L-DOPA, the metabolic precursor of dopamine, is thought to palliate the deficit of dopamine in the striatum of parkinsonian patients. Nonetheless, this presentation will show that serotonergic, but not dopaminergic neurons, are involved in L-DOPA-stimulated dopamine extracellular levels. One consequence is that the striatum does not appear as a specific site of action of L-DOPA if we refer to its dopaminergic action.


Contact: Bruno GUIARD, REMEMBeR team, CRCA

Jeudi 25 Janvier

Guillaume Salbreux
Séminaire axe CSB
Titre : Physics of epithelial folding
* Salle Conférence IBCG
Marie-Elise Galoppini
Autre séminaire
Titre : MiniSéminaire Mentoring
* Salle Conférence Vandel

Vendredi 26 Janvier

Séminaire CBI
Titre : Cell Plasticity: learning from tissue morphogenesis to tackle tumour progression
* Salle Conférence IBCG
Séminaire axe GD
Titre : Cohesin regulation in space and time
* Salle Conférence Vandel

Cohesin is a ring-shaped protein complex able to capture DNA molecules. This DNA trapping ability impinges on a large variety of biological processes such as chromosome segregation and repair, nuclear organization and gene expression through intra-chromosomal DNA looping. Alteration of cohesin function is involved in many human pathologies such as cancer and developmental defects; sterility, miscarriage and trisomy when the germline is affected.

The wide variety of biological functions controlled by cohesin implies that cohesin functions must be tightly regulated in space and time. In particular, one might expect cohesin functions to be controlled by cell cycle regulators in order to translate input signals into an appropriate physiological response. The mechanisms by which cohesin functions are governed by the cell cycle machinery are however largely unknown.

Using the fission yeast Schizosaccharomyces pombe our group has identified two new regulators that modulate cohesin behavior by controlling the phosphorylation status of its Rad21 subunit. I’ll present published data about Protein Phosphatase 4 regulation of sister-chromatid cohesion (Birot et al., 2017) and then I’ll move on current work suggesting that cohesin deposition along chromosomes is controlled by Cyclin Dependent Kinase mediated phosphorylation of Cohesin.

 Recent papers:

A second Wpl1 anti-cohesion pathway requires dephosphorylation of fission yeast kleisin Rad21 by PP4.

Birot A, Eguienta K, Vazquez S, Claverol S, Bonneu M, Ekwall K, Javerzat JP, Vaur S. EMBO J. 2017 May 15;36(10):1364-1378. 

The Fun30 chromatin remodeler Fft3 controls nuclear organization and chromatin structure of insulators and subtelomeres in fission yeast.

Steglich B, Strålfors A, Khorosjutina O, Persson J, Smialowska A, Javerzat JP, Ekwall K.

PLoS Genet. 2015 Mar 23;11(3):e1005101. 

Pds5 promotes cohesin acetylation and stable cohesin-chromosome interaction.

Vaur S, Feytout A, Vazquez S, Javerzat JP. EMBO Rep. 2012 Jun 29;13(7):645-52. 

Dheur S, Saupe SJ, Genier S, Vazquez S, Javerzat JP. Mol Cell Biol. 2011 Mar;31(5):1088-97. 

Molecular biology. Directing the centromere guardian.

Javerzat JP. Science. 2010 Jan 8;327(5962):150-1.

Samedi 27 Janvier

Dimanche 28 Janvier

Université Paul Sabatier
118 Route de Narbonne

31062 TOULOUSE Cedex

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