C/D RNAs protect the tRNA-methionine from cleavage by angiogenin

Patrice Vitali and Tamas Kiss of the LBME have identified new C/D RNAs capable of guiding 2'-O-ribose methylation on a transfer RNA: the tRNA-methionine.

In eukaryotes, only ribosomal RNAs and snRNAs of the spliceosome were known to be chemically modified via this machinery. They also showed that under oxidative stress conditions, this modification protects the tRNA-methionine from cleavage by angiogenin.

This study has been published recently in the journal Genes and Development.

Read more (in french) : CNRS INSB website

Reference :

Cooperative 2'-O-methylation of the wobble cytidine of human elongator tRNAMet(CAT) by a nucleolar and a Cajal body-specific box C/D RNP.

Vitali P, Kiss T.

Genes Dev. 2019 Jun 6. doi: 10.1101/gad.326363.119. [Epub ahead of print]

Contacts :

Patrice Vitali

Tamas Kiss