Patrice Vitali and Tamas Kiss of the LBME have identified new C/D RNAs capable of guiding 2'-O-ribose methylation on a transfer RNA: the tRNA-methionine.
In eukaryotes, only ribosomal RNAs and snRNAs of the spliceosome were known to be chemically modified via this machinery. They also showed that under oxidative stress conditions, this modification protects the tRNA-methionine from cleavage by angiogenin.
This study has been published recently in the journal Genes and Development.
Read more (in french) : CNRS INSB website
Reference :
Vitali P, Kiss T.
Genes Dev. 2019 Jun 6. doi: 10.1101/gad.326363.119. [Epub ahead of print]
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