The extrusion of cells remodels their tissue of origin

Tissues are essentially made of epithelial cells that form monolayers. During development, cells can sometimes leave these monolayers through a process called epithelial-mesenchymal transition. This process corresponds to the extrusion of a cell out of the tissue and its transformation into a migratory cell. In a study published in the journal Nature Communications, Magali Suzanne's team from LBCMCP-CBI shows that by extricating themselves from this monolayer, cells can deform their original tissue, thus actively participating in tissue remodeling during development.

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Reference :

Mechanical impact of epithelial-mesenchymal transition on epithelial morphogenesis in Drosophila
Gracia M, Theis S, Proag A, Gay G, Benassayag C, Suzanne M.
Nat Commun. 2019 Jul 4;10(1):2951. doi: 10.1038/s41467-019-10720-0.

Contacts :

Magali Suzanne & Corinne Benassayag