May the force be with the supracellular network to change shape !

Actomyosin networks, formed by the assembly of the proteins actin and myosin, play a crucial role in the morphogenesis of organs and tissues. Using the Drosophila ovary as a study model, Xiaobo Wang of LBCMCP and his collaborators explored the origin and function of supracellular actomyosin networks. In this study, they demonstrate that a supracellular network controlled by the small GTPase Cdc42 establishes polarized forces and leads to the extension of the egg chamber in Drosophila. These results were obtained by combining Drosophila genetics, imaging of living tissue, optogenetics and laser ablation.

This work shows for the first time how a supracellular network is formed in the basal domain of cells to generate the forces necessary to change the shape of an epithelial tissue.

Read more (in french) : https://insb.cnrs.fr/fr/cnrsinfo/que-la-force-soit-avec-le-reseau-supracellulaire-pour-changer-de-forme

Reference

A Cdc42-mediated supracellular network drives polarized forces and Drosophila egg chamber extension.
Popkova A, Stone OJ, Chen L, Qin X, Liu C, Liu J, Belguise K, Montell DJ, Hahn KM, Rauzi M, Wang X.
Nat Commun. 2020 Apr 21;11(1):1921. doi: 10.1038/s41467-020-15593-2.

Contact

Xiaobo Wang

CNRS Researcher at Laboratoire de Biologie Cellulaire et Moléculaire du Contrôle de la Prolifération - Centre de Biologie Intégrative (LBCMCP-CBI)