RNA Surveillance in the third domain of life

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Archaea, the third domain of living organisms, alongside eukaryotes and bacteria, are now considered to be essential models for studying the molecular mechanisms of the cell and understanding the history of the evolution of living organisms. The results, published in the journal Nucleic Acid Research by LMGM researchers, provide new perspectives on the molecular actors responsible for monitoring cellular RNA and thus regulating gene expression.

Read more : News on the INSB website

Reference :

RNA processing machineries in Archaea: the 5'-3' exoribonuclease aRNase J of the β-CASP family is engaged specifically with the helicase ASH-Ski2 and the 3'-5' exoribonucleolytic RNA exosome machinery

Phung DK, Etienne C, Batista M, Langendijk-Genevaux P, Moalic Y, Laurent S, Liuu S, Morales V, Jebbar M, Fichant G, Bouvier M, Flament D, Clouet-d'Orval B.

Nucleic Acids Res. 2020 Feb 7. pii: gkaa052. doi: 10.1093/nar/gkaa052. [Epub ahead of print]

Researcher contact :

Béatrice Clouet d’Orval, CNRS researcher in  « laboratoire de Biologie Moléculaire et Génétique Moléculaires » (LMGM-CBI, CNRS-UT3-Paul Sabatier)

© Béatrice Clouet-d’Orval

Figure : Schematic representation of the tree of life with bacteria, archaea and eukaryotes. The molecular machines (in green) and enzymes (exo-ribonucleases in blue / RNA helicases in orange), in charge of RNA degradation, found in common in the three branches of living organisms are represented. These enzymes and machines are the key players in the metabolic pathways managing the quantity and quality of RNA and are therefore fundamental in the regulation of gene expression in the cell.