Research conducted by a Swiss team and Anna Mattout of the LBCMCP shows for the first time that there is, in the worm, another level of post-transcriptional regulation, which specifically degrades RNA from heterochromatin. In addition to a better general understanding of post-transcriptional regulation, this discovery opens up therapeutic possibilities from a completely new angle in various pathologies, particularly cancer. This study was recently published in Nature Cell Biology.
Mattout, A., Gaidatzis, D., Padeken, J. et al. LSM2-8 and XRN-2 contribute to the silencing of H3K27me3-marked genes through targeted RNA decay. Nat Cell Biol 22, 579–590 (2020).