Towards a better understanding of the molecular mechanisms that control fertility

The LSD1 protein is a key chromatin regulator and its absence causes infertility. However, the functions of LSD1 in the ovaries are poorly characterized.

Researchers working on Drosophila have discovered that during oogenesis, LSD1 regulates genes crucial for development and represses transposable elements, mobile DNA sequences whose activation can lead to infertility.

This study, conducted by an international team including LBCMCP researchers, was published in the journal Nucleic Acids Research.

Read more : Sur le site de l’Institut des sciences biologiques

 

Reference :

A dual role of dLsd1 in oogenesis: regulating developmental genes and repressing transposons.

Lepesant JMJ, Iampietro C, Galeota E, Augé B, Aguirrenbengoa M, Mercé C, Chaubet C, Rocher V, Haenlin M, Waltzer L, Pelizzola M, Di Stefano L.

Nucleic Acids Res. 2019 Dec 4. pii: gkz1142. doi: 10.1093/nar/gkz1142. [Epub ahead of print]

Researcher contact :

Luisa Di Stefano, chercheuse Inserm au Laboratoire de biologie cellulaire et moléculaire du contrôle de la prolifération (LBCMCP-CBI, CNRS/UT3-Paul Sabatier)