Control of neuronal identity in the zebrafish

Presentation

The team has a long-standing interest in understanding the molecular mechanisms underlying the development of the nervous system using the zebrafish embryo as a model. We are using a complementary set of molecular, genetic and imaging strategies to address topics including how proneural transcription factors coordinate neurogenesis and morphogenesis in the developing olfactory placode, how intercellular signalling cascades interact to specify different neuronal subtypes in the pineal gland, and how left-right asymmetry is establish in the brain. More recently, we have begun to explore how the pineal gland regulates a set of simple light-dependent behaviours.

Projets

Modelling Ribosomopathies in zebrafish

Development and function of the pineal gland, a simplified retina.

Establishing left-right asymmetry brain asymmetry

Proneural gene function & olfactory placode development

Publications

• Raphaël Aguillon, Romain Madelaine, Marion Aguirrebengoa, Harendra Guturu, Sandra Link, Pascale Dufourcq, Virginie Lecaudey, Gill Bejerano, Patrick Blader, Julie Batut.
  Morphogenesis is transcriptionally coupled to neurogenesis during peripheral olfactory organ development
  Development
  2020 Nov
• Wei L, Al Oustah A, Blader P, Roussigné M.
  Notch signaling restricts FGF pathway activation in parapineal cells to promote their collective migration.
  Elife
  2019 Sep https://www.insb.cnrs.fr/fr/cnrsinfo/migration-de-cellules-dans-le-cerveau-de-poisson-un-duel-entre-notch-et-fgf
• Cau E, Ronsin B, Bessière L, Blader P..
  A Notch-mediated, temporal asymmetry in BMP pathway activation promotes photoreceptor subtype diversification.
  PLoS Biol.
  2019 Jan https://insb.cnrs.fr/fr/cnrsinfo/choix-dune-identite-cellulaire-une-breve-histoire-de-temps
• Myriam Roussigné, Lu Wei, Erika Tsingos, Franz Kuchling, Mansour Alkobtawi, Matina Tsalavouta, Joachim Wittbrodt, Matthias Carl, Patrick Blader, and Stephen W. Wilson.
  Left/right asymmetric collective migration of parapineal cells is mediated by focal FGF signaling activity in leading cells
  Proc Natl Acad Sci U S A
  2018 Oct http://www4.cnrs-dir.fr/insb/recherche/parutions/articles2018/m-roussigne.html
• Aguillon R, Batut J, Subramanian A, Madelaine R, Dufourcq P, Schilling TF, Blader P.
  Cell-type heterogeneity in the early zebrafish olfactory epithelium is generated from progenitors within preplacodal ectoderm
  Elife, pii: e32041. doi: 10.7554/eLife.32041
  2018 Jan http://www.cnrs.fr/insb/recherche/parutions/articles2018/p-blader.html

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Alumni

QUILLIEN Aurélie PhD Student

MADELAINE Romain PhD Student

GARRIC Laurence PhDStudent/Post-doc FRM

SAPEDE Dora  Post-doctoral Fellow