Transcriptional control of cell fate specification by Mediator complex subunits during development

Muriel Boube

CR CNRS
05 61 55 87 48

Team members

  Researcher
  • Muriel Boube
  Technical staff
  • Sandra Bernat-Fabre
  • Denis Jullien
  PhD student
  • Adeline Payet

Thèmes de recherche

    Presentation

    The conserved multiprotein Mediator (MED) complex links DNA-bound transcription factors to RNA polymerase II (PolII). Despite a general role of Mediator in regulating nearly all PolII-dependent genes, studies from our and other labs have shown that a half of the 30 MED subunits have specific functions. Consistently, many human diseases have been linked to MED dysfunctions. Whereas most studies have been done from cultured cells, our team takes advantage of the Drosophila genetic model to investigate the molecular bases underlying the functional specificity of dedicated MED subunits in the transcriptional control of cell fate specification in-vivo.

    Projets

    Project

    Publications

    View all publications

    Funding

           

    Institute

    Université Paul Sabatier
    118 Route de Narbonne

    31062 TOULOUSE Cedex
    France

    Annuaire général