Transcriptional control of cell fate specification by Mediator complex subunits during development

Presentation

The conserved multiprotein Mediator (MED) complex links DNA-bound transcription factors to RNA polymerase II (PolII). Despite a general role of Mediator in regulating nearly all PolII-dependent genes, studies from our and other labs have shown that a half of the 30 MED subunits have specific functions. Consistently, many human diseases have been linked to MED dysfunctions. Whereas most studies have been done from cultured cells, our team takes advantage of the Drosophila genetic model to investigate the molecular bases underlying the functional specificity of dedicated MED subunits in the transcriptional control of cell fate specification in-vivo.

Projets

Publications

• Immarigeon C, Bernat-Fabre S, Augé B, Faucher C, Gobert V, Haenlin M, Waltzer L, Payet A, Cribbs DL, Bourbon* HM, Boube* M.
  Drosophila Mediator Subunit Med1 Is Required for GATA-Dependent Developmental Processes: Divergent Binding Interfaces for Conserved Coactivator Functions
  Mol Cell Biol.
  2019 Mar
• Lacomme M, Medevielle F, Bourbon HM, Thierion E, Kleinjan DJ, Roussat M, Pituello F, Bel-Vialar S..
  A long range distal enhancer controls temporal fine-tuning of PAX6 expression in neuronal precursors.
  Dev Biol.
  2018 Apr
• Tessé* S, Bourbon* HM, Debuchy R, Budin K, Dubois E, Liangran Z, Antoine R, Piolot T, Kleckner N, Zickler D, Espagne E..
  Asy2/Mer2: an evolutionarily conserved mediator of meiotic recombination, pairing, and global chromosome compaction.
  Genes and Development
  2017 Oct
• Schuettengruber, B., Bourbon, HM., Di Croce, L., Cavalli, G..
  Genome Regulation by Polycomb and Trithorax: 70 Years and Counting
  Cell, 171, 1, 34-57
  2017 Sep
• Mojica-Vázquez LH, Benetah MH, Baanannou A, Bernat-Fabre S, Deplancke B, Cribbs DL, Bourbon* HM and Boube* M.
  Tissue-specific enhancer repression through molecular integration of cell signaling inputs
  PLoS Genet. 2017 Apr 10;13(4):e1006718. doi: 10.1371/journal.pgen.1006718
  2017 Apr *Co-corresponding authors

View all publications

Funding