Histone demethylases in development and in cancer

Luisa Di stefano


CR
05 61 55 85 99

Team members

  Researcher
  • Luisa Di stefano
  Associate professor
  • David Cribbs
  Technical staff
  • Camille Chaubet
  Master student
  • Ines Selmi
  • Olashade Laleye

Presentation

In recent years, the histone lysine demethylase LSD1 has emerged as a key chromatin regulator. LSD1 plays an essential role in regulating cell fate and differentiation and it is often deregulated in cancer. However, our understanding of the biological role of LSD1 is still incomplete. Our goal is to shed light on the mechanisms by which LSD1 control chromatin structure and the transcriptionof genes and transposable elements during Drosophila development and in cancer. 
We aim to answer three main questions: 
1) How does LSD1 activity control normal development ? 
2) Which proteins direct LSD1 targeting and to which genomic regions? 
3) Which signaling pathways control LSD1 activity?

Publications

  • Julie M.J. Lepesant, Carole Iampietro, Eugenia Galeota, Benoit Auge, Marion Aguirrenbengoa, Clementine Merce, Camille Chaubet, Vincent Rocher, Marc Haenlin, Lucas Waltzer, Mattia Pelizzola and Luisa Di Stefano.
    A dual role of dLsd1 in oogenesis: regulating developmental genes and repressing transposons
    Nucleic Acid Research
    2019 Dec
  • Altuna M, Urdánoz-Casado A, Sánchez-Ruiz de Gordoa J; Zelaya MV, Labarga A, Lepesant JMJ, Roldán M; Blanco-Luquin I, Perdones A; Larumbe R; Jericó I; Echavarri C; IMéndez-López I; Di Stefano L.; Mendioroz, M..
    DNA methylation signature of human hippocampus in Alzheimer’s disease is linked to neurogenesis.
    Clinical Epigenetics
    2019 Jun
  • Wayne O. Miles, Julie M. J. Lepesant, Jessie Bourdeaux, Manuela Texier, Marc A. Kerenyi, Makoto Nakakido, Ryuji Hamamoto, Stuart H. Orkin, Nicholas J. Dyson, Luisa Di Stefano.
    The LSD1 Family of Histone Demethylases and the Pumilio Posttranscriptional Repressor Function in a Complex Regulatory Feedback Loop
    Molecular and Cellular Biology
    2015 Dec Mol Cell Biol. 2015 Dec;35(24):4199-211. doi: 10.1128/MCB.00755-15.
  • 2015 Jan Dietz KN, Di Stefano L, Maher RC, Zhu H, MacDonald ME, Gusella JF and Walker JA. The Drosophila Huntington’s disease gene ortholog dhtt influences chromatin regulation during development. Human Molecular Genetics 2015, Jan 15; 24(2): 330-45
  • 2013 Jan Di Stefano L and Dyson N. The emerging roles for histone demethylases in the modulations of signaling pathways. Biomolecular Concepts. 2013; 4(1): 13–27

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Funding

           

Alumni

Julie LEPESANT, PhD

Carole IAMPIETRO, PhD

Institute

Université Paul Sabatier
118 Route de Narbonne

31062 TOULOUSE Cedex
France

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