Publications
Publications de l'équipe Besson
- Creff J., Nowosad A., Prel A., Pizzocarro A., Aguirrebengoa M., Duquesnes N., Callot C., Jungas T., Dozier C. and A. Besson.
p57Kip2 acts as a transcriptional corepressor to regulate intestinal stem cell fate and proliferation
Cell Rep
2023 Jun doi: https://doi.org/10.1016/j.celrep.2023.112659. PMID: 37327110 - Dozier C., Montigny A., Viladrich M., Culerrier R, Combier J.P., Besson A.* et S. Plaza*. *: equal contribution.
Small ORFs as New Regulators of Pri-miRNAs and miRNAs Expression in Human and Drosophila
Int. J. Mol. Sci
2022 May 23, 5764. https://doi.org/10.3390/ijms23105764. PMID: 35628573 - Talmont F.*, Mitri E.*, Dozier C., Besson A., Cuvillier O.‡ and A. Hatzoglou‡. *, ‡: Equal contribution.
Sphingosine 1-Phosphate Receptor 5 (S1P5) deficiency promotes proliferation and immortalization of Mouse Embryonic Fibroblasts
Cancers
2022 Mar 14 (7), 1661. https://doi.org/10.3390/cancers14071661. PMID: 35406433 - Nowosad A. and A. Besson.
Lysosomes at the crossroads of cell metabolism, cell cycle and stemness
Int. J. Mol. Sci
2022 Feb 23, 2290. https://doi.org/10.3390/ijms23042290. PMID: 35216401 - Nowosad A. and A. Besson.
Real-time monitoring and automatic quantification of starvation-induced autophagy in mouse embryonic fibroblasts using a live high-throughput imaging system
STAR Protocols
2021 Dec 2, 100966. https://doi.org/10.1016/j.xpro.2021.100966. PMID: 34825223 - Nowosad A., Creff J., Jeannot P., Codogno P., Manenti S., Nguyen L. and A. Besson.
p27Kip1 controls autophagic vesicle trafficking in glucose deprived cells via the regulation of ATAT1-mediated microtubule acetylation
Cell Death Dis
2021 May 12: 481. https://doi.org/10.1038/s41419-021-03759-9. PMID 33986251 - Prel A.*, Dozier C.*, Combier J.P., Plaza S.+, and A. Besson+. *, + Equal contribution.
Evidence that regulation of pri-miRNA/miRNA expression is not a general rule of miPEPs function in humans
Int. J. Mol. Sci.
2021 Mar 22, 3432. doi.org/10.3390/ijms22073432. PMID: 33810468 - Cartel M., Mouchel P.L., Gotanègre M., David L., Bertoli S., Mansat-De Mas V., Besson A., Sarry J.E., Manenti S., and C. Didier.
Inhibition of ubiquitin-specific protease 7 sensitizes acute myeloid leukemia to chemotherapy
Leukemia. 35: 417-432
2021 Feb PMID 32447346 - Creff J., Malaquin L.* and A. Besson*. *Equal contribution.
In vitro models of intestinal epithelium: towards bioengineered systems
J. Tissue Eng. 12: 1-16
2021 Feb Doi: 10.1177/2041731420985202. Review. PMID 3410438 - Nowosad A. and A. Besson.
CDKN1B/p27 regulates autophagy via the control of Ragulator and MTOR activity in amino acid-deprived cells
Autophagy
2020 Oct doi.org/10.1080/15548627.2020.1831217. PMID: 33016184 - Creff J. and A. Besson.
Functional versatility of the CDK inhibitor p57Kip2
Front. Cell Dev. Biol
2020 Oct Oct 7;8:584590. doi: 10.3389/fcell.2020.584590. eCollection 2020. Review. PMID: 33117811 - Nowosad A., Jeannot P., Callot C., Creff J., Perchey R.T., Joffre C., Codogno P., Manenti S. and A. Besson.
p27 controls Ragulator and mTOR activity in amino acid-deprived cells to regulate the autophagy-lysosomal pathway and coordinate cell cycle and cell growth
Nat. Cell Biol
2020 Sep 22: 1076-1090. (cover article). PMID 32807902 - Gagniac L., Rusidzé M., Boudou F., Cagnet S., Adlanmerini M., Jeannot P., Gaide N., Giton F., Besson A., Weyl A., Gourdy P., Raymond-Letron I., Arnal J.F., Brisken C. and F. Lenfant .
Membrane expression of the estrogen receptor ERα is required for intercellular communications in the mammary epithelium
Development
2020 Feb pii: dev.182303. doi: 10.1242/dev.182303. PMID: 32098763 - Sueur G., Boutet A., Gotanègre M., Mansat-De Mas V., Besson A., Manenti S.*, and S, Bertoli*. *Equal contribution.
STAT5-dependent regulation of CDC25A by miR-16 controls proliferation and differentiation in FLT3-ITD acute myeloid leukemia
Sci. Rep
2020 Jan 10: 1906. https://doi.org/10.1038/s41598-020-58651-x. PMID: 32024878 - Creff J., Courson R., Mangeat T., Foncy J., Souleille S., Thibault C., Besson A.* and L. Malaquin*.
Fabrication of 3D scaffolds reproducing intestinal epithelium topography by high-resolution 3D stereolithography. *Equal contribution
Biomaterials
2019 Aug 5;221:119404. doi: 10.1016/j.biomaterials.2019.119404. PMID 31419651 - Perchey R.T.*, Tonini L.*, Tosolini M., Fournié J.J., Lopez F., Besson A. and F. Pont.
PTMSelect: optimization of protein modification discovery by mass spectrometry. *Equal contribution
Sci. Rep
2019 Mar 9: 4181. doi.org/10.1038/s41598-019-40873-3. PMID: 30862887 - Calvayrac O.*, Nowosad A.*, Lin L.P., Figarol S., Jeannot P., Serres M.P., Callot C., Perchey R.T., Creff J., Taranchon-Clermont E., Rouquette I., Favre G., Pradines A., Manenti S., Mazieres J., Lee H. and A. Besson. *Equal contribution .
Cytoplasmic p27Kip1 promotes tumorigenesis via the suppression of RhoB activity
J. Pathol
2019 Jan 247: 60-71. PMID: 30206932 - Perchey R.T., Serres M.P., Nowosad A., Creff J., Gay A., Callot C., Manenti S., Margolis R.L., Hatzoglou A., and A. Besson.
p27Kip1 regulates the microtubule bundling activity of PRC1
BBA Mol. Cell Res
2018 Nov 1865: 1630-1639. PMID: 30327204 - Adam K, Cartel M, Lambert M, David L, Yuan L, Besson A, Mayeux P, Manenti S, Didier C.
A PIM-CHK1 signaling pathway regulates PLK1 phosphorylation and function during mitosis
J Cell Sci
2018 Aug doi: 10.1242/jcs.213116. PMID: 29976560 - Morelli G.*, Aviel Even A.*, Le Bail R., Godin J.D., Gladwyn-Ng I., Peyre E., Hassan B.A., Besson A., Rigo J.M., Weil M., Brône B., and L. Nguyen.
p27Kip1 regulates axonal transport by modulating microtubule acetylation. *Equal contribution
Cell Rep
2018 May 23: 2429-2442. PMID: 29791853 - Gallastegui E., Domuro C., Serratosa J., Larrieux A., Sin L., Martinez J., Besson A., Morante J.M., Orlando S., Aligué R., Fariñas I., Pujol M.J. and O. Bachs.
p27Kip1 regulates alpha-synuclein expression
Oncotarget
2018 Mar 9: 16368-16379. PMID: 29662651 - Heydt Q., Larrue C., Saland E., Bertoli S., Sarry J.E., Besson A., Manenti S., Joffre C.* and V. Mansat-De Mas*.
Oncogenic FLT3-ITD supports autophagy via ATF4 in acute myeloid leukemia progression
Oncogene
2018 Feb 37: 787-797. *Equal contribution. PMID: 29059168 - Phillips A.H., Li O., Gay A., Besson A. and R.W. Kriwacki..
Mapping interactions between p27 and RhoA that stimulate cell migration.
J. Mol. Biol.
2018 Jan 430: 751-758. PMID: 29410088 - Jeannot P. and A. Besson.
Invadopodia regulation: a new function for p27 in cellular invasion
Med. Sci. (Paris)
2017 Dec 33: 1021-1023. PMID: 29261483 - Jeannot P. and A. Besson.
Cortactin function in invadopodia
Small GTPases
2017 Dec Dec 31:1-15. doi: 10.1080/21541248.2017.1405773. PMID: 29172953 - Biçer A., Islam A., Orlando S., Gallastegui E., Besson A., Aligué R., Pujol M.J. and O. Bachs.
ChIP-Seq Analysis Identifies p27Kip1-Target Genes Involved in Cell Adhesion and Cell Signalling in Mouse Embryonic Fibroblasts
PLOS One
2017 Nov 12(11): e0187891. doi: 10.1371/journal.pone.0187891. PMID: 29155860 - Dozier C., Mazzolini L., Cénac C., Froment C., Burlet-Schiltz O., Besson A., and S. Manenti.
CyclinD-CDK4/CDK6 complexes phosphorylate CDC25A at Ser40 and contribute to the regulation of its stability
Oncogene
2017 Jun 36: 3781-3788. PMID: 28192398 - Jeannot P., Nowosad A., Perchey R., Callot C., Bennana E., Katsube T., Mayeux P., Guillonneau F., Manenti S. and A. Besson.
p27Kip1 promotes invadopodia turnover and invasion through the regulation of the PAK1/Cortactin pathway
eLife
2017 Mar Mar 13;6. pii: e22207. doi: 10.7554/eLife.22207. PMID: 28287395 - Jungas T., Besson A. and A. Davy.
Eph-ective control of cytokinesis
Cell Cycle
2017 Feb 16: 241-242. PMID: 27786587 - Gallastegui E., Biçer A., Orlando S., Besson A., Pujol M.J. and O. Bachs.
p27Kip1 represses the Pitx2-mediated expression of p21Cip1 and regulates DNA replication during cell cycle progression
Oncogene
2017 Jan 36: 350–361. PMID: 27270438 - Mazzolini L., Broban A., Burlet-Schiltz O., Besson A., Manenti S. and Dozier C..
Phosphorylation of CDC25A on Serine 283 in G2 by CDK/Cyclin complexes accelerates mitotic entry
Cell Cycle
2016 Oct 15: 2742-2752. PMID: 27580187 - Jungas T., Perchey R.T., Fawal M., Callot C., Froment C., Burlet-Schiltz O., Besson A.* and A. Davy A*.
Eph-mediated tyrosine phosphorylation of Citron Kinase controls abscission
J. Cell Biol
2016 Aug 214: 555-569. (cover article). *Equal contribution. PMID: 27551053 (Faculty of 1000 recommended article.) - Duquesnes N., Callot C., Jeannot P., Daburon V., Nakayama K.I., Manenti S., Davy A., and A. Besson.
p57Kip2 knock-in mouse reveals CDK-independent contribution in Beckwith-Wiedemann syndrome
J Pathol
2016 Jul 239: 250-261. PMID 27015986 - Jeannot P., Baer R., Callot C., Duquesnes N., Guerra C., Guillermet-Guibert J., Bachs O. and A. Besson.
Loss of p27Kip1 promotes metaplasia in the pancreas via regulation of Sox9 expression
Oncotarget
2015 Nov 6: 35880-35892. PMID 26416424 - Orlando S., Gallastegui E., Besson A., Abril G., Aligué R., Pujol M.J. and O. Bachs.
p27Kip1 and p21Cip1 collaborate in the regulation of transcription by recruiting cyclin-Cdk complexes on the promoters of target genes
Nucl. Acid Res
2015 Aug 43: 6860-6873. PMID 26071952 - Agarwal A., Mackenzie R.J., Besson A., LaTocha D.H., Fleischman A.J., Duquesnes N., Eide C.A., Vasudevan K.B., Loriaux M.M., Firpo E., Cortes J.E., O’Hare T., Roberts J.M., Druker B.J. and M.W. Deininger.
BCR-ABL1 promotes leukemia by converting p27 into a cytoplasmic oncoprotein
Blood
2014 Nov 124: 3260-3273. PMID 25293778 - Gui P., Labrousse A., Van Goethem E., Besson A., Maridonneau-Parini I. and V. Le Cabec.
Rho/ROCK pathway inhibition by CDK inhibitor p27Kip1 participates in the onset of macrophage 3D-mesenchymal migration
J. Cell Sci
2014 Sep 127: 4009-4023. PMID 25015295 - Godin J.D.*, Thomas N.*, Laguesse S.*, Malinouskaya L., Close P., Malaise O., Purnelle A., Raineteau O., Campbell K., Fero M., Moonen G., Malgrange B., Chariot A., Metin C., Besson A., and L. Nguyen.
p27Kip1 controls cortical interneuron migration by coordinating actin and microtubule cytoskeletons
Dev. Cell
2012 Oct 23: 729-744. *Equal contribution. PMID 23022035 - Pippa R., Espinosa L., Gundem G., García-Escudero R., Dominguez A., Orlando S., Gallastegui E.,Saiz C., Besson A., Pujol M.J., López-Bigas N., Paramio J.M., Bigas A., and O. Bachs.
p27Kip1 represses transcription by direct interaction with p130/E2F4 at the promoters of target genes
Oncogene
2012 Sep 31: 4207-4220. PMID 22179826 - Leclercq B. and A. Besson.
[A new role for p27Kip1 in mitosis ?]
Med. Sci. (Paris)
2012 Jun 28: 570-572. PMID 22805127 - Serres M.P., Kossatz U., Chi Y., Roberts J.M., Malek N.P. and A. Besson.
p27Kip1 controls cytokinesis via the regulation of Citron-Kinase activity
J. Clin. Invest
2012 Mar 122: 844-858. PMID 22293177 - Serres M.P., Zlotek-Zlotkiewicz E., Concha C., Gurian-West M., Daburon V., Roberts J.M. and A. Besson.
Cytoplasmic p27 is oncogenic and cooperates with Ras both in vivo and in vitro
Oncogene
2011 Jun 30: 2846-2858. PMID 21317921 - Dalvai M., Schubart K., Besson A.*†, and P. Matthias*.
Oct-1 is required for mTOR induced G1 cell cycle arrest
Cell Cycle
2010 Oct 9: 3933-3944. *Equal contribution. †Corresponding author. PMID 20935455 - Concha C. and A. Besson.
p27Kip1 is needed…for glioma invasion
Cell Cycle
2010 Apr 9: 1457. PMID 20421714 - Serres M.P. and A. Besson.
[Critical role for p27 in mediating the antitumoral activity of a proteasome inhibitor]
Med. Sci. (Paris)
2009 Mar 25: 213-214. PMID 19361375 - Besson A., S.F. Dowdy, and J.M. Roberts.
CDK Inhibitors: Cell Cycle Regulators and Beyond
Dev. Cell
2008 Feb 14: 159-169. Review. PMID 18267085 - Besson A.
[p27Kip1, tumor suppressor…and oncogene?]
Med. Sci. (Paris)
2007 Dec 23: 1089-1091. PMID 18154709 - Besson A., H.C. Hwang, S.L. Donovan, S. Cicero, M. Gurian-West, D. Johnson, B.E. Clurman, M.A. Dyer, and J.M. Roberts.
Discovery of an oncogenic activity in p27Kip1 that causes stem cell expansion and a multiple tumor phenotype
Genes Dev
2007 Jul 21: 1731-1746. (cover article). PMID 17626791 (Highlighted in Genes Dev. (Perspectives), 21 : 1703-1706 ; Nature Reviews Cancer (Highlights) 7 : 637 ; Cell Res. (Research highlights) 17: 832-833) - Nguyen L., A. Besson, J.M. Roberts, and F. Guillemot.
Coupling the molecular pathways underlying cortical neurogenesis
Cell Cycle
2006 Oct 5: 2314-2318. Review. PMID 17102618 - Nguyen L., A. Besson, J. Heng, C. Schurrmans, L. Teboul, A. Philpott, J.M. Roberts, and F. Guillemot.
p27Kip1 independently promotes neuronal differentiation and migration in the cerebral cortex
Genes Dev
2006 Jun 20: 1511-1524. PMID 16705040 - Besson A., M. Gurian-West, X. Chen, K.S. Kelly-Spratt, C.J. Kemp, and J.M. Roberts.
A pathway in quiescent cells that controls p27Kip1 stability, subcellular localization and tumor suppression
Genes Dev
2006 Jan 20: 47-64. PMID 16391232 - Besson A., R.K. Assoian, and J.M. Roberts.
Regulation of the cytoskeleton: an oncogenic function for CDK inhibitors?
Nature Rev. Cancer
2004 Dec 4: 948-955. Review. PMID 15573116 - Besson A., M. Gurian-West, A. Schmidt, A. Hall, and J.M. Roberts.
p27Kip1 modulates cell migration through the regulation of RhoA activation
Genes Dev
2004 Apr 18: 862-876. (cover article). PMID 15078817 (Highlighted in Nature (News and Views) 428:705-707; Nature Reviews Molecular Cell Biology (Highlights) 5:335; Genes Dev. (Perspective) 18:851-855; Dev. Cell (Previews) 6: 458-459.). Faculty of 1000 recommended article - Le D.M., A. Besson, D.K. Fogg, K.S. Choi, D.M. Waisman, C.G. Goodyer, B. Rewcastle, and V.W. Yong.
Exploitation of astrocytes by glioma cells to facilitate invasiveness:A mechanism involving MMP-2 and the uPA–Plasmin Cascade
J. Neurosci
2003 May 23: 4034-4043. PMID 12764090 - Besson A., T.L. Wilson, and V.W. Yong.
The anchoring protein RACK1 links protein kinase C ε to integrin β chains: Requirement for adhesion and motility
J. Biol. Chem
2002 Jun 277: 22073-22084. PMID 11934885 - Corley S.M., U. Ladiwala, A. Besson, and V.W. Yong.
Astrocytes attenuate oligodendrocyte death in vitro through an α6 integrin-laminin dependent mechanism
Glia
2001 Dec 36: 281-294. PMID 11746766 - Besson A., A. Davy, S.M. Robbins, and V.W. Yong.
Differential activation of ERKs to focal adhesions by PKC ε is required for PMA-induced adhesion and migration of human glioma cells
Oncogene
2001 Nov 20: 7398-7407. PMID 11704869 - Besson A. and V.W. Yong.
Mitogenic signaling pathways and their relationship to cell cycle control in astrocytomas
J. Neurooncol
2001 Nov 51: 245-264. Review. PMID 11407596 - Vecil G.G., P.H. Larsen, S.M. Corley, L.M. Herx, A. Besson, C.G. Goodyer, and V.W. Yong.
Interleukin-1 is a key regulator of matrix-metalloproteinase-9 expression in human neurons in culture and following mouse brain trauma in vivo
J. Neurosci. Res
2000 Jul 61: 212-224. PMID 10878594 - Besson A., and V.W. Yong.
Involvement of p21/Waf1/Cip1 in protein kinase C Alpha-induced cell cycle progression
Mol. Cell. Biol
2000 Jul 20: 4580-4590. PMID 10848585 - Besson A., S.M. Robbins, and V.W. Yong.
PTEN/MMAC1/TEP1 in signal transduction and tumorigenesis
Eur. J. Biochem
1999 Aug 263: 605-611. Review. PMID 10469123
