Team
Team Manager: Besson Arnaud
Presentation
Current projects in our team are:
1. Decipher the roles of the CDK inhibitor p27Kip1 in the regulation of cell metabolism and autophagy.
2. Investigate the role of p57Kip2 in the control of intestinal stem cell fate and proliferation and design novel in vitro models by high resolution 3D printing to reproduce the intestinal epithelium.
3. Investigate the mechanisms regulating the mitotic kinase Citron Kinase and determine its potential as a therapeutic target in glioblastoma.
– Creff J., Nowosad A., Prel A., Pizzocarro A., Aguirrebengoa M., Duquesnes N., Callot C., Jungas T., Dozier C. and A. Besson. p57Kip2 acts as a transcriptional corepressor to regulate intestinal stem cell fate and proliferation Cell Rep 2023 Jun doi: https://doi.org/10.1016/j.celrep.2023.112659. PMID: 37327110
– Dozier C., Montigny A., Viladrich M., Culerrier R, Combier J.P., Besson A.* et S. Plaza*. *: equal contribution. Small ORFs as New Regulators of Pri-miRNAs and miRNAs Expression in Human and Drosophila Int. J. Mol. Sci 2022 May 23, 5764. PMID: 35628573
– Talmont F.*, Mitri E.*, Dozier C., Besson A., Cuvillier O.‡ and A. Hatzoglou‡. *, ‡: Equal contribution. Sphingosine 1-Phosphate Receptor 5 (S1P5) deficiency promotes proliferation and immortalization of Mouse Embryonic Fibroblasts Cancers 2022 Mar 14 (7), 1661. PMID:35406433
– Nowosad A. and A. Besson.
Lysosomes at the crossroads of cell metabolism, cell cycle and stemness
Int. J. Mol. Sci 2022 Feb 23, 2290. PMID: 35216401
– Nowosad A. and A. Besson.
Real-time monitoring and automatic quantification of starvation-induced autophagy in mouse embryonic fibroblasts using a live high-throughput imaging system
STAR Protocols 2021 Dec 2, 100966. PMID: 34825223
