My work focuses on understanding the mechanisms of gene expression changes in cellular senescence. I notably explore the regulation and function of unannotated non-coding RNAs (vlincRNAs, antisense RNAs, read-through RNAs, circular RNAs) and X-linked gene dosage in this process in human cells. We use several approaches including genome-wide analyses (RNA-seq, ChIP-seq,…) and CRISPR editing.