Audrey Dussutour (CRCA-CBI) has been awarded prestigious funding from the Human Frontier Science Program (HFSP) for the project Molecular memories in single cells: An integrated approach to how cells learn in collaboration with Saad BHAMLA (Georgia institute of technology-Atlanta, United States) and Wanze CHEN (Shenzhen institute of advanced technology, China). This award supports international collaboration in basic research and encourages researchers around the world to adopt innovative approaches to better understand biological complexity.
Recent discoveries suggest that RNA may be involved in the storage and transmission of memories. The project will explore this hypothesis through the study of a unicellular organism, Spirostomum ambiguum, and immune cells, specifically macrophages. It aims to characterize the learning capacities of these two cell types and to identify the underlying molecular mechanisms. Using Live-seq, a cutting-edge technology that allows cellular activity to be monitored over time without destroying them, gene expression will be tracked in living cells, enabling researcher to observe changes in behaviour and genetic activity as learning occurs.
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