Team
Team Manager: Theveneau Eric
Presentation
Our lab focuses on mechanisms of cell dynamics: epithelial-mesenchymal transition, directional cell migration, adhesion and polarity. We use embryos as tools to better understand the function of key players in development and cancer progression with a specific focus on metalloproteinases, transcription factors and adhesion molecules.
We use a mix of experimental and computational strategies. Our primary models are the neural tube, the neural crest and the mesoderm of chicken and Xenopus embryos.
Project 3
– Despin-Guitard E, Rosa VS, Plunder S, Mathiah N, Van Schoor K, Nehme E, Merino-Aceituno S, Egea J, Shahbazi MN, Theveneau E, Migeotte I. Non-apical mitoses contribute to cell delamination during mouse gastrulation. Nat Commun. 2024 Aug 28;15(1):7364. doi: 10.1038/s41467-024-51638-6. PubMed PMID: 39198421; PubMed Central PMCID: PMC11358383.
– Plunder S, Danesin C, Glise B, Ferreira MA, Merino-Aceituno S, Theveneau E. Modelling variability and heterogeneity of EMT scenarios highlights nuclear positioning and protrusions as main drivers of extrusion. Nat Commun. 2024 Aug 28;15(1):7365. doi: 10.1038/s41467-024-51372-z. PubMed PMID: 39198505; PubMed Central PMCID: PMC11358417.
– Acloque H, Yang J, Theveneau E. Epithelial-to-mesenchymal plasticity from development to disease: An introduction to the special issue. Genesis. 2024 Feb;62(1):e23581. doi: 10.1002/dvg.23581. Epub 2023 Dec 14. PubMed PMID: 38098257; PubMed Central PMCID: PMC11021161.
– Gouignard N, Bibonne A, Mata JF, Bajanca F, Berki B, Barriga EH, Saint-Jeannet JP, Theveneau E. Paracrine regulation of neural crest EMT by placodal MMP28. PLoS Biol. 2023 Aug;21(8):e3002261. doi: 10.1371/journal.pbio.3002261. eCollection 2023 Aug. PubMed PMID: 37590318; PubMed Central PMCID: PMC10479893.
– Danesin C, Ferreira MA, Degond P, Theveneau E. Anteroposterior elongation of the chicken anterior trunk neural tube is hindered by interaction with its surrounding tissues. Cells Dev. 2021 Dec;168:203723. doi: 10.1016/j.cdev.2021.203723. Epub 2021 Jul 17. PubMed PMID: 34284169.
– Yang J, Antin P, Berx G, Blanpain C, Brabletz T, Bronner M, Campbell K, Cano A, Casanova J, Christofori G, Dedhar S, Derynck R, Ford HL, Fuxe J, García de Herreros A, Goodall GJ, Hadjantonakis AK, Huang RYJ, Kalcheim C, Kalluri R, Kang Y, Khew-Goodall Y, Levine H, Liu J, Longmore GD, Mani SA, Massagué J, Mayor R, McClay D, Mostov KE, Newgreen DF, Nieto MA, Puisieux A, Runyan R, Savagner P, Stanger B, Stemmler MP, Takahashi Y, Takeichi M, Theveneau E, Thiery JP, Thompson EW, Weinberg RA, Williams ED, Xing J, Zhou BP, Sheng G. Guidelines and definitions for research on epithelial-mesenchymal transition. Nat Rev Mol Cell Biol. 2020 Jun;21(6):341-352. doi: 10.1038/s41580-020-0237-9. Epub 2020 Apr 16. Review. PubMed PMID: 32300252; PubMed Central PMCID: PMC7250738.
– Andrieu C, Montigny A, Bibonne A, Despin-Guitard E, Alfandari D, Théveneau E. MMP14 is required for delamination of chick neural crest cells independently of its catalytic activity. Development. 2020 Apr 12;147(7). doi: 10.1242/dev.183954. PubMed PMID: 32280063; PubMed Central PMCID: PMC7174838.
– Bajanca F, Gouignard N, Colle C, Parsons M, Mayor R, Theveneau E. In vivo topology converts competition for cell-matrix adhesion into directional migration. Nat Commun. 2019 Apr 3;10(1):1518. doi: 10.1038/s41467-019-09548-5. PubMed PMID: 30944331; PubMed Central PMCID: PMC6447549.
Affiliation
