La sérotonine produite par des neurones régule l’hématopoïèse de stress induite en réponse à un stress immunitaire tel que le parasitisme par des guêpes. La glande lymphatique est l’organe hématopoïétique de la drosophile.
The hematopoietic stem cells of the vertebrate bone marrow are responsible for the production of blood and immune cells (hematopoiesis). Their maintenance depends on signals from their tissue microenvironment, known as the ‘haematopoietic niche’.
Xiaohui Liu, Marianne Montemurro, Nathalie Vanzo and Michèle Crozatier have demonstrated, using the Drosophila model, the existence of a dialogue between the nervous system and the cells of the hematopoietic niche in response to immune stress. They have shown how serotonin, a neurotransmitter produced by neurons, controls the function of the hematopoietic niche and thus regulates hematopoiesis induced in response to immune stress.
These results could have important implications for the study of human hematopoiesis, particularly in the context of diseases such as leukemia, immune deficiency and age-related disorders.
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