Légende : Photo de l’équipe projet réunie au Centre de Biologie Intégrative (CBI – CNRS / Université de Toulouse) dans le cadre du lancement de la collaboration CALIDES entre Eurofins CALIXAR, le CNRS, l’Université de Toulouse et l’Université Paris Cité.
The CNRS, University of Toulouse, Université Paris Cité and Eurofins CALIXAR, a company specialised in the development and production of membrane proteins, have agreed to launch a collaborative project aimed at accelerating the preclinical stages of pharmaceutical development. Currently, almost 60% of drugs approved by the Food and Drug Administration target membrane proteins, even though these proteins are particularly complex to study. Although they represent around 30% of the human genome, less than 5% of their three- dimensional structures have been elucidated to date.
As part of a CIFRE thesis (Eurofins CALIXAR), Magdalena Szczuka, a doctoral student in Matthieu Chavent‘s team (LMGM-CBI) aims to combine molecular dynamics simulations of these proteins with artificial intelligence. These original approaches will make it possible to optimise laboratory developments, making them more precise and more specific, and to identify high-quality therapeutic targets for pharmaceutical research and drug development.
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