Team
IVEP
Team manager: Jeanson Raphaël
Presentation
We study the determinants of phenotypic plasticity across different biological scales, from cells to individuals and entire animal societies. Phenotypic plasticity, the ability of a genotype to produce different phenotypes in response to environmental variation, is one of the key mechanisms through which organisms adapt to changing conditions. Using an integrated and interdisciplinary approach, we are exploring how biological entities, be they cells, individuals or animal societies, react to and integrate environmental stimuli to produce adapted behavioral responses.
Project 1
Although single-cell organisms lack the complex hardware of a true brain, they inhabit complex ecological niches and face the same decision-making challenges as animals: they must feed and mate, adapt to changing conditions, sense and avoid predators, and find suitable microclimates. Equipped with a ‘biological toolkit’ of behavior-generating processes, these organisms can handle environments of varying complexity. This toolkit includes sensing and perception, valence, learning and memory, anticipation, signal integration, and communication, collectively referred to as basal cognition. This concept is supported by the variety of metabolic cellular processes single-cell organisms use to sense, evaluate, and monitor their internal and external environments, and the diverse functional outputs generated from these sensory inputs. We aim to explore the link between basal cognition and behavioral plasticity, demonstrating how fundamental cognitive processes within a single cell can influence an organism’s ability to adapt and respond to environmental changes.
Project 2
Foraging is one of the best studied behaviors in the context of optimal models. However, most work has been focused on complex animals, which have advanced sensory abilities (such as vision). We are trying to understand how simple organisms, from motile bacteria to lower invertebrates, manage to find and consume food efficiently despite their strong cognitive and sensory limitations. To do this, we are developing new models for Optimal Foraging where these limitations are taken into account explicitly, and testing them on the nematode Caenorhabditis elegans. Our theoretical work also covers other areas of decision-making, and notably collective decisions.
Project 3
Compared to solitary lifestyles, living in social groups provides many advantages for its members, such as better protection from predators, increased efficiency in brood care, information sharing regarding food or habitat resources. However, social life also implies sharing diseases via interactions with other group members and leading even to epidemics in some cases, within the social group. Interestingly, during outbreaks, some individuals become ill or die, while others recover quickly or show no signs of the disease. These differences among individuals highlight several fundamental questions, such as why are some individuals susceptible to infectious diseases while others resist better? Or can an organism’s access to resources increase its resistance or susceptibility to parasites? This project aims to understand how variability in health, behaviour and immune defense is coordinated within an individual and within an ant society.
Project 4
Reproductive division of labor is a defining feature of eusocial societies. The separation between reproductive and non-reproductive individuals has set the stage for increased colony complexity in social insects, and is likely responsible for the evolutionary and ecological success of ants, bees and termites. Despite the importance of the division of labor in the evolution of social insects, the mechanisms behind task specialization remain largely unexplored. This project aims to investigate the evolution of division of labor and uncover how reproductive and non-reproductive roles emerged. In particular, we explore the influence of environmental and social factors on individual development and how these factors contributed to the emergence of caste determination in social insects.
Project 5
Sociality spans a remarkable range of forms, from the simple aggregations to the most integrated societies. Nevertheless, our understanding of the proximal mechanisms that drive transitions between different levels of social organization remains limited. In arthropods, we are studying how changes in the social context experienced early in development shape later social behavior in solitary species. Our overall aim is to identify the mechanisms and signaling pathways that may have been co-opted during evolution to lead to the emergence of permanent sociality. In addition, we are employing comparative methods between solitary and social species to examine if changes in social organizations are accompanied by variations in the levels of behavioral flexibility and brain plasticity.
Team members
– Moch C, Zou L, Pythoud N, Fillon E, Bourgeois G, Graille M, Carapito C, Chapat C*. The YTHDF1-3 proteins are bidirectionally influenced by the codon content of their mRNA targets. BioRxiv. November 20, 2023. doi.org/10.1101/2023.11.20.565808
– Oudart M, Avila-Gutierrez K, Moch C, Dossi E, Milior G, Boulay AC, Gaudey M, Moulard J, Lombard B, Loew D, Bemelmans AP, Rouach N, Chapat C, Cohen-Salmon M. The ribosome-associated protein RACK1 represses Kir4.1 translation in astrocytes and influences neuronal activity. Cell Reports. 2023 May 30;42(5):112456.
– Zou L, Moch C, Graille M, Chapat C*. The SARS-CoV-2 protein NSP2 impairs the silencing capacity of the human 4EHP-GIGYF2 complex. iScience. 2022 July 15;25(7):104646. doi: 10.1016/j.isci.2022.104646 (*corresponding author)
– Zhang X, Chapat C, Wang P, Choi JH, Li Q, Luo J, Wiebe S, Kim SH, Robichaud N, Karam IF, Dai D, Hackett AP, Lin R, Alain T, Yang L, Jafarnejad SM, Sonenberg N. microRNA-induced translational control of antiviral immunity by the cap-binding protein 4EHP. Molecular Cell. 2021 Mar 18. 81(6):1187-1199.e5.
– Hazra D, Chapat C, Graille M. m6A mRNA Destiny: Chained to the rhYTHm by the YTH-Containing Proteins. Genes. 2019, 10(1), 49
– Jafarnejad SM*, Chapat C*, Matta-Camacho E, Gelbart IA, Hesketh GG, Arguello M, Garzia A, Kim SH, Attig J, Shapiro M, Morita M, Khoutorsky A, Alain T, Gkogkas CG, Stern-Ginossar N, Tuschl T, Gingras AC, Duchaine TF, Sonenberg N. Translational control of ERK signaling through miRNA/4EHP-directed silencing. Elife. 2018 Feb 7;7. pii: e35034. doi: 10.7554 (#co-first authors)
– -Garzia A, Jafarnejad SM, Meyer C, Chapat C, Gogakos T, Morozov P, Amiri M, Shapiro M, Molina H, Tuschl T, Sonenberg N. The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs. Nature Communications. 2017;8:16056.
– Chapat C*, Chettab K, Simonet P, Wang P, De La Grange P, Le Romancer M, Corbo L. Alternative splicing of CNOT7 diversifies CCR4-NOT functions. Nucleic Acids Research. 2017 Aug 21;45 (14):8508-8523. (*corresponding author)
– Chapat C*, Jafarnejad SM#, Matta-Camacho E, Hesketh GG, Gelbart IA, Attig J, Gkogkas CG, Alain T, Stern-Ginossar N, Fabian MR, Gingras AC, Duchaine TF, Sonenberg N. Cap-binding protein 4EHP effects translation silencing by microRNAs. Proc Natl Acad Sci USA. 2017 May 23;114(21):5425-5430.
Affiliation
