Célia Plisson-Chastang, Paulo Espirito Santo, and Laura Plassart (MCD-CBI), along with their colleagues, have shed light on the functioning of a human protein complex called R2SP, which is essential for the formation of cilia. Cilia are tiny structures found on the surface of certain cells and play a crucial role in certain vital functions. The R2SP complex controls the correct assembly of the proteins that make up these cilia, thereby ensuring their proper functioning.
Using cutting-edge techniques in structural biology, Célia Plisson-Chastang’s team has described the three-dimensional structure of the R2SP complex, as well as the molecular mechanisms underlying its action. This work will ultimately lead to a better understanding of certain rare diseases, known as ciliopathies, which manifest as respiratory disorders in children (problems with mucus clearance in the airways) and/or male infertility (problems with sperm motility).
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