Gaëlle Legube (MCD CBI) has been awarded the ARC Foundation’s Grand Prix Oberling Haguenau, which recognises the excellence of the cancer research carried out by her team. This €150,000 prize recognises the team’s work on double-strand breaks in DNA and the way in which these breaks are repaired in actively transcribed regions of the genome – a particularly complex context. This research now plays a central role in international research into genome stability.
This work has profoundly changed the way biologists view DNA repair, no longer as a simple technical mechanism, but as an integrated process, closely linked to the architecture of the nucleus, gene activity and chromosome dynamics.
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