Since the beginning of my career, my research has focused on understanding the molecular mechanisms underlying genetic instability, particularly in the context of tumor development and aging. I have specifically studied the role of specialized DNA polymerases and their deregulation in cancer, as well as the impact of replication stress and DNA repair defects as key drivers of genetic instability.
Currently, as part of the Chromatin and Cell Proliferation team, I am investigating the consequences of oxidative damage on transcription, DNA repair, and mutagenesis. To achieve this, I use optogenetic tools that enable the targeted generation of reactive oxygen species directly on DNA.
In addition, I contribute to several Master’s-level workshops on topics such as telomere maintenance and cancer, the concept of synthetic lethality, and genome dynamics.
I obtained my HDR in 2018.