My research aims to characterize cerebral plasticity underlying learning and memory functions in the healthy brain and in mouse models of Alzheimer's disease. In particular, i want to understand the role played by adult-generated hippocampal neurons in memory formation. We recently started investigating how endogenous neural stem cells from the diseased adult brain may be manipulated to become fully functional neurons able to drive cognitive rehabilitation.
Some fundings : ANR (2021; 2014; 2013; 2011; 2011; 2006; 2006), the European Union (2015; 2005), the Occitanie Region (2023; 2013; 2012), the Fyssen Foundation (2020), France Alzheimer Association (2009; 2015, 2024), the Fondation Recherche sur le Cerveau (2009; 2018; 2023), IHU HealthAge (2025)
https://www.researchgate.net/profile/Claire-Rampon
Selection of publications :
Fauré LMP, Gauzin S,Lejards C, Rampon C* & Verret L* (2025) Fine Social Discrimination of Siblings in Mice: Implications for Early Detection of Alzheimer's Disease. Neurobiol of Disease 13:206:106799. doi: 10.1016/j.nbd.2025.106799
Coutens B, Lejards C, Bouisset G, Verret L, Rampon C*, Guiard BP* (2023) Enriched environmental exposure reduces the onset of action of the serotonin norepinephrin reuptake inhibitor venlafaxine through its effect on parvalbumin interneurons plasticity in mice. Transl Psychiatry 26;13(1):227.
Peyron C and Rampon C (2020) Young Neurons Tickle Memory during REM Sleep. Neuron 107 (397-398) https://doi.org/10.1016/j.neuron.2020.07.018.
Richetin K, Leclerc, C, Toni N, Gallopin T, Pech S, Roybon L & Rampon C. Genetic manipulation of adult-generated hippocampal neurons rescues memory in a mouse model of Alzheimer’s disease. (2015) Brain, 138: 440-55
Trouche S, Bontempi B, Roullet P & Rampon C. Recruitment of adult-generated neurons into functional hippocampal networks contributes to updating and strengthening of spatial memory. (2009) Proc. Nat. Ac. Sci, USA 106(14):5919-24.
Rampon C, Jiang CH, Dong H, Tang Y-P, Lockhart DJ., Schultz P.G., Tsien J.Z. & Hu Y. Effects of environmental enrichment on gene expression in the brain. Proc. Nat. Ac. Sci. (2000) 97, 12880-12884.
Rampon C*, Tang Y-P*, Goodhouse J, Shimizu E, Kyin M & Tsien JZ. Enrichment induces structural changes and recovery from nonspatial memory deficits in CA1 NMDAR1-knockout mice. Nat. Neurosci. (2000) 3, 238-244.
