Chromatin Dynamics and Cell Proliferation

Présentation

We study how chromatin dynamics govern cell fate/proliferation through:

a) Nucleosome-positioning, which controls the accessibility of key genomic features such as gene promoters/bodies or replication origins.

b) Higher-order chromatin folding for the regulation of transcription/replication, which involves DNA looping to mediate long-range interactions between distinct/functional elements.

We investigate how specific chromatin modifiers (Mes-4/NSD, Hypb etc.), regulators (insulator and co-factors), and oncogenes (dref, …) impact transcription or replication through chromatin dynamics.

To this end, we employ biochemistry, molecular genetics, cellular biology combined with computational biology of high throughput sequencing data to tackle key aspects of chromatin organization. 

https://github.com/CuvierLab/

 

 

Projets

HiCfeat

G4Hunter

Chromatin-based clonal inheritance

Chromatin dynamics

Publications

• Mancheno-Ferris A, Immarigeon C, Rivero A, Depierre D, Schickele N, Fosseprez O, Chanard N, Aughey G, Lhoumaud P, Anglade J, Southall T, Plaza S, Payre F, Cuvier O, Polesello C..
  Crosstalk between chromatin and Shavenbaby defines transcriptional output along the Drosophila intestinal stem cell lineage.
  iScience.
  2023 Dec
• Colin L, Reyes C, Berthezene J, Maestroni L, Modolo L, Toselli E, Chanard N, Schaak S, Cuvier O, Gachet Y, Coulon S, Bernard P, Tournier S..
  Condensin positioning at telomeres by shelterin proteins drives sister-telomere disjunction in anaphase.
  Elife.
  2023 Nov
• Thenin-Houssier S, Machida S, Jahan C, Bonnet-Madin L, Abbou S, Chen HC, Tesfaye R, Cuvier O, Benkirane M..
  POLE3 is a repressor of unintegrated HIV-1 DNA required for efficient virus integration and escape from innate immune sensing.
  Sci Adv.
  2023 Nov
• Contreras X, Depierre D, Akkawi C, Srbic M, Helsmoortel M, Nogaret M, LeHars M, Salifou K, Heurteau A, Cuvier O, Kiernan R..
  PAPγ associates with PAXT nuclear exosome to control the abundance of PROMPT ncRNAs.
  Nat Commun.
  2023 Oct
• Depierre D, Perrois C, Schickele N, Lhoumaud P, Abdi-Galab M, Fosseprez O, Heurteau A, Margueron R, Cuvier O..
  Chromatin in 3D distinguishes dMes-4/NSD and Hypb/dSet2 in protecting genes from H3K27me3 silencing.
  Life Sci Alliance.
  2023 Sep

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Financements

             

Anciens membres

Olivier Fosséprez (Postdoctoral Researcher)

David Dépierre (Postdoctoral Researcher)

Raphaël Mourad (Maître de Conférence)

Jun Liang (Assistant Professor)

Priscillia Lhoumaud (Chargée de Recherche)

Laurent Lacroix (Chargé de Recherche)

Franck Court (Chargé de Recherche)

Emmanuelle Guillou (Maître de Conférence)

Eldon Emberly (Associate Professor)

Pascal Martin (Ingénieur de Recherche)

Sophie Queille (Ingénieure de Recherche)