Chromatin Dynamics and Cell Proliferation

Olivier Cuvier


CR INSERM
05 61 33 59 56

Membres de l'équipe

  Chercheur
  • Olivier Cuvier
  • Stéphane Schaak
  Soutien technique
  • Charlène Perrois
  Etudiant en Thèse
  • Thibault Sansen
  • David Depierre
  • Olivier Fosseprez
  Etudiant en Master
  • Nicolas Chanard
  --
  • Refka Askri

Thèmes de recherche

    Présentation

    We study how chromatin dynamics govern cell fate/proliferation through:

    a) Nucleosome-positioning, which controls the accessibility of key genomic features such as gene promoters/bodies or replication origins.

    b) Higher-order chromatin folding for the regulation of transcription/replication, which involves DNA looping to mediate long-range interactions between distinct/functional elements.

    We investigate how specific chromatin modifiers (Mes-4/NSD, Hypb etc.), regulators (insulator and co-factors), and oncogenes (dref, …) impact transcription or replication through chromatin dynamics.

    To this end, we employ biochemistry, molecular genetics, cellular biology combined with computational biology of high throughput sequencing data to tackle key aspects of chromatin organization. 

    https://www-lbme.biotoul.fr/uk/equipes/grpcuvier/index.html

     

     

    Projets

    HiCfeat

    G4Hunter

    Chromatin-based clonal inheritance

    Chromatin dynamics

    Publications

    Voir toutes les publications

    Financements

           

    Anciens membres

    Raphaël Mourad (Maître de Conférence)

    Jun Liang (Assistant Professor)

    Priscillia Lhoumaud (Postdoctoral researcher)

    Laurent Lacroix (Chargé de Recherche)

    Franck Court (Chargé de Recherche)

    Emmanuelle Guillou (Maître de Conférence)

    Eldon Emberly (Associate Professor)

    Pascal Martin (Ingénieur de Recherche)

    Gael Micas

    Sophie Queille

    Université Paul Sabatier
    118 Route de Narbonne

    31062 TOULOUSE Cedex
    France

    Annuaire général