Chromatin Dynamics and Cell Proliferation

Olivier Cuvier


DR INSERM
05 61 33 59 56

Membres de l'équipe

  Chercheur
  • Olivier Cuvier
  • Stéphane Schaak
  Soutien technique
  • Refka Askri
  • Charlène Perrois
  Post-doctorant
  • Robel Tesfaye
  Doctorant
  • Naomi Schickele
  • Aurore Benoit

Présentation

We study how chromatin dynamics govern cell fate/proliferation through:

a) Nucleosome-positioning, which controls the accessibility of key genomic features such as gene promoters/bodies or replication origins.

b) Higher-order chromatin folding for the regulation of transcription/replication, which involves DNA looping to mediate long-range interactions between distinct/functional elements.

We investigate how specific chromatin modifiers (Mes-4/NSD, Hypb etc.), regulators (insulator and co-factors), and oncogenes (dref, …) impact transcription or replication through chromatin dynamics.

To this end, we employ biochemistry, molecular genetics, cellular biology combined with computational biology of high throughput sequencing data to tackle key aspects of chromatin organization. 

https://github.com/CuvierLab/

 

 

Projets

HiCfeat

G4Hunter

Chromatin-based clonal inheritance

Chromatin dynamics

Publications

Voir toutes les publications

Financements

             

Anciens membres

Olivier Fosséprez (Postdoctoral Researcher)

David Dépierre (Postdoctoral Researcher)

Raphaël Mourad (Maître de Conférence)

Jun Liang (Assistant Professor)

Priscillia Lhoumaud (Chargée de Recherche)

Laurent Lacroix (Chargé de Recherche)

Franck Court (Chargé de Recherche)

Emmanuelle Guillou (Maître de Conférence)

Eldon Emberly (Associate Professor)

Pascal Martin (Ingénieur de Recherche)

Sophie Queille (Ingénieure de Recherche)

Université Paul Sabatier
118 Route de Narbonne

31062 TOULOUSE Cedex
France


05 61 33 58 00

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