Gut Development and Homeostasis

Présentation

Our research is aimed towards understanding the regulatory principles of epithelial renewal in the mammalian gut — how this astonishingly dynamic tissue is initially established during development, and how it is maintained in adult tissue homeostasis, using the mouse gut as a model.

We focus on the regulatory role of mechanical forces in establishment and maintenance of epithelial turnover and integrity, integrating cell- and tissue-level mechanics with the physiological context of the mammalian gut.

Our experimental approach combines live tissue imaging (in vivo and ex vivo) with genetic, pharmacological and force perturbations and theoretical modelling.

We are currently looking for postdocs and PhD students, with a strong background in cell & developmental biology. 
Postdoc candidates should send their application including CV, and statement of motivation and research interests to denis.krndija[at]univ-tlse3.fr
PhD student candidates should apply directly at the Graduate School (Ecole Doctorale), but can contact us first for more information.

Projets

Publications

• Verhulsel M, Simon A, Bernheim-Dennery M, Gannavarapu VR, Geremie L, Ferraro D, Krndija D, Talini L, Viovy JL, Vignjevic DM.
  Developing an advanced gut on chip model enabling the study of epithelial cells/fibroblasts interactions
  Lab on a Chip
  2021 Jan
• El Marjou F, Jouhanneau C, Krndija D.
  Targeted Transgenic Mice Using CRISPR/Cas9 Technology
  Methods Mol Biol
  2021 Jan
• Lagoutte E, Villeneuve C, Fraisier V, Krndija D, Deugnier MA, Chavrier P, Rossé C.
  A new pipeline for pathophysiological analysis of the mammary gland based on organoid transplantation and organ clearing.
  J Cell Sci
  2020 Jun
• Krndija D*, Fairhead M.
  IGF1R undergoes active and directed centripetal transport on filopodia upon receptor activation.
  Biochem J
  2019 Dec *corresponding author
• Krndija D*, El Marjou F, Guirao B, Richon S, Leroy O, Bellaiche Y, Hannezo E, Matic Vignjevic D.
  Active cell migration is critical for steady-state epithelial turnover in the gut
  Science
  2019 Aug *corresponding author; this work was highlighted in Science, Nature Reviews Molecular Cell Biology, and Current Biology

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Financements