Mécanismes de la maturation des ARN ribosomiques chez l'homme


  • Pierre-Emmanuel Gleizes
  • Franck Delavoie
  • Charlotte Guette
  • Sarah Le Page
  • Nathalie Montel-Lehry
  • Marie-Françoise O'donohue
  • Paul Troalen

Specific mechanisms of pre-ribosomal RNA processing in human cells

Project leaders : Marie-Françoise O'Donohue, Pierre-Emmanuel Gleizes

Our investigation of human pre-rRNA processing has revealed mechanisms specific to mammalian cells when compared to the well-studied yeast S. cerevisiae, as visualized by the presence of distinct intermediate RNAs and the involvement of additional enzymes. Hence, we recently showed the unexpected requirement of 3'-5' exonucleases in the maturation of the 18S rRNA precursors. We are currently being characterizing the enzymes involved in this process.



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