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Séminaires CBI de la semaine du 16-10-2023 au 22-10-2023

Lundi 16 Octobre

CODE séminaire public
Titre : Séminaire PICS CODE
4R4-RDC | Salle Conférence (182 pers.)

Mardi 17 Octobre

Forum on ERC funding in TOULOUSE
Autre séminaire
Titre : Forum on ERC funding in TOULOUSE
Nathalie Vanzo
STADE séminaire interne
Titre : Extracellular vesicles mediate cell communication in the Drosophila lymph gland during stress hematopoiesis
4R4-RDC | Salle Conférence (182 pers.)
Hugo Lebrette Team MycoMet, LMGM-CBI
SYSMIC séminaire interne
Titre : A look at a free radical trying to break free
4R4-RDC | Salle Conférence (182 pers.)

Mercredi 18 Octobre

Autre séminaire
Titre : TMBI junior
4R4-RDC | Salle Conférence (182 pers.)

Jeudi 19 Octobre

Xiabo Team
CELLDYN séminaire interne
Titre : “Cues of myosin oscillation in development: biochemical or mechanics? ”
IBCG | Salle Conférence (100 pers.)

Vendredi 20 Octobre

Pablo Huertas DNA double strand break repair and human disease" au Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER) à Séville (ESPAGNE).
CBI séminaire public
Titre : “ Regulating the repair of broken chromosomes beyond the nucleus: a connection with cancer appearance, evolution and prognosis”
4R4-RDC | Salle Conférence (182 pers.)
RNA séminaire interne
Titre : Réunion PICS RNA internal
IBCG | Bibliothèque (22 pers.)
Nicassio Francesco Italian Institute of Technology
RNA séminaire public
Titre : “Interplay of Coding and Noncoding RNAs in Cancer Mechanisms”
IBCG | Salle Conférence (100 pers.)

The eukaryotic genome contains non-coding elements that contribute, both at RNA (lncRNAs, miRNAs) and DNA level (enhancers), to shaping the cell transcriptome in physiology and disease. A key scientific priority is to be able to understand the interplay of the coding and non-coding elements within cellular programs, providing the functional mechanisms of transcriptional and epigenetic plasticity. In cancer biology, plasticity is a key mechanism, fueling both cancer heterogeneity and evolution, which are at the basis of the most threatening aspects of tumor biology, such as the onset of tumor, the resistance to therapies and the occurrence of metastasis. Here we present a thorough investigation of cancer heterogeneity and adaptive phenotypes, using as a model the triple-negative subtype of breast cancer (TNBC) and focusing on the transcriptional and epigenetic mechanisms at the basis of cancer plasticity. Using single-cell multi-omics and lineage tracing, we investigated the predictive characteristics of cancer clones primed for in vivo tumour initiation and drug tolerance within the same cancer population. We identified the existence of multiple subpopulations, only minimally overlapping, that support the adaptive evolution of cancer through parallel trajectories. We propose a technological framework that can be used to investigate the non-coding layer within such cancer complexity. Our approach combining high-resolution sequencing, including Nascent RNA sequencing and Third Generation Native RNA Sequencing by Nanopores, with functional analysis provided by CRISPR-interference (CRISPRi) tools, was used to isolate and validate lncRNAs, enhancers and miRNAs-based mechanisms involved in TNBC, revealing separate and mutual paths participating at cancer plasticity.

Curiosity Seminar
Titre : Curiosity seminar
4R4-RDC | Salle Conférence (182 pers.)
CODE séminaire public
Titre : PICS CODE séminaire
IBCG | Salle Conférence (100 pers.)

Samedi 21 Octobre

Dimanche 22 Octobre

Université Paul Sabatier
118 Route de Narbonne

31062 TOULOUSE Cedex

05 61 33 58 00

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