Genetic recombination and the cell cycle

François Cornet

Chargé de Recherche, CNRS
05 61 33 59 84

Team members

  • Manuel Campos
  • Bao Ton-Hoang
  • Estelle Brendon
  • Philippe Rousseau
  Technical staff
  • Luu Le Phan Thai
  • Carine Pagès


We are studying the global organization of bacterial genomes and its dynamics during the cell cycle and evolution by horizontal gene transfer. Using Escherichia coli as a model organism and a multi-scale approach involving biochemistry, biophysics, molecular genetics and cell biology, we put emphasis on the last steps of chromosome segregation and their integration with the cell cycle and cell division. We also investigate how the molecular machines involved in late segregation are domesticated by mobile genetic elements for their integration as bona fide parts of their host genome.


Genesis and maintenance of bacterial chromosomes

Internal control of the Xer recombination machine


  • Sayyed HE, Le Chat L, Lebailly E, Vickridge E, Pages C, Cornet F, Cosentino Lagomarsino M, Espéli E..
    Mapping Topoisomerase Iv Binding and Activity Sites on the E . Coli Genome
    PLoS Genet
    2016 Jan
  • Fournes F, Crozat E, Pages C, Tardin C, Salomé L, Cornet F*, Rousseau P*.
    FtsK translocation inhibits recombination at a Xer site involved in horizontal gene transfer
    Proc Nat Acad Sci USA
    2016 Jan
  • 2014 Jan Crozat E, Fournes F, Cornet F, Hallet B, Rousseau P. (2014) Resolution of Multimeric Forms of Circular Plasmids and Chromosomes. In Plasmid Biology, M Tomalsky and JC Alonso Ed., ASM press. pp 251-273.microbiolspec 2(5): doi:10.1128/microbiolspec.PLAS-0025-2014.
  • 2014 Jan Crozat E, Rousseau P, Fournès F, Cornet F. (2014) The FtsK Family of DNA Translocases Finds the Ends of Circles. J Mol Microbiol Biotechnol 2014;24:396–408 DOI: 10.1159/000369213.
  • 2014 Jan Bouet J-Y, Souf M, Lebailly E, Cornet F. (2014) Mechanisms for chromosome segregation. Current Opinion in Microbiology 2014, 22:60–65.

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Université Paul Sabatier
118 Route de Narbonne

31062 TOULOUSE Cedex

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