MItochondria- & ExperieNce- Dependent neuronal plastIcity, NeurodeGeneration (MINDING)

Presentation

A mitochondrial gate to neuronal plasticity and neurodegeneration.

Finely tuned mitochondrial functions, from energy supply to cell homeostasis, are vital for highly specialized and energy-demanding cells, like neurons. A precise dynamics of mitochondrial fusion and fission events underlies their quality control and adaptability to cellular needs. As an illustration, pathologies directly associated to mutations in key fusion proteins, like Type 1 Dominant Optic Atrophy (OPA1 mutation), are mainly neurodegenerative. Reciprocally, progressive neurodegenerative diseases such as Alzheimer’s are linked not only to impairments of mitochondrial functions (energy, oxidative stress) but also to impairments of mitochondrial dynamics and turn-over.

Mainly centered on in vitro and in vivo DOA models, our projects aim at deciphering, and in fine modeling, the mechanisms of mitochondrial impact on neuronal homeostasis and synaptic plasticity. Spanning from adult neurogenesis to axonal degeneration, we also want to understand the impact of mitochondrial morphological and functional plasticity on experience-dependent neuronal plasticity and complex brain functions such as animal cognition.

Collaborators :

• Claire Rampon, Lionel Mouledous, Sébastien Lopez (CBI-CRCA), Camille Lejards (CBI-CRCA),
• Raffele Leva (CBI-LMGM),
• Joel Bordeneuve-Guibé (ISAE-Supaero, Toulouse),
• Daniel Dunia (CPTP, Toulouse),
• Jean-Michel Peyrin (IBPS, Paris),
• Pascal Reynier (CHU Angers, France),
• Laurent Roybon (Lundt, Sweden),
• Bernd Wissinger (U. Tubingen, Germany)

 

Projets

Protective potential of the X protein in DOA (DOAX)

Mitophagy or Apoptosis: a choice Made in neurons by Bnip3-Opa1 interaction ? (MAMBO)

Mitochondria and Axonal degeneration in DOA: a story of shape and function.

MOdeling to predict the eVolution and trEatment of dominant Optic atrophy and OPA1 gene deficit related diseases pathogenesis (MOVE ONE) & identification of Reactive Oxygen Species and opA1 (ROSA)

Mitochondria, adult neurogenesis & learning and memory (MITOGATE)

Publications

• Trinovita Andraini, Lionel Moulédous, Petnoi Petsophonsakul, Cédrick Florian, Sébastien Gauzin, Marlène Botella-Daloyau, Macarena Arrázola, Kamela Nikolla, Adam Philip, Alice Leydier, Manon Marque, Laetitia Arnauné-Pelloquin, Pascale Belenguer, Claire Rampon† and Marie-Christine Miquel†*.
  Mitochondrial OPA1 deficiency is associated to reversible defects in spatial memory related to adult neurogenesis in mice
  eNeuro
  2023 Nov
• Atamena D, Gurram V, Petsophonsakul P, Khosrobakhsh F, Arrázola MS, Botella M, Wissinger B Szelechowski M, Belenguer P. .
  Genetic background modulates phenotypic expressivity in OPA1 mutated mice, relevance to DOA pathogenesis
  Front Mol Neurosci.
  2023 Sep
• Millet AMC, Coustham C, Champigny C, Botella M, Demeilliers C, Devin A, Galinier A, Belenguer P, Bordeneuve-Guibé J, Davezac N.
  OPA1 deficiency impactoxidative metabolism in cycling cells: a translational approach for degenerative diseases
  Dis Model Mech.
  2023 Jul
• Texier B, Prime M, Atamena D, Belenguer P, Szelechowski M..
  Mortalin/Hspa9 involvement and therapeutic perspective in Parkinson's disease
  Neural Regen Res
  2023 Feb
• Guyonnet S, Rolland Y, Takeda C, Ousset PJ, Ader I, Davezac N, Dray C, Fazilleau N, Gourdy P, Liblau R, Parini A, Payoux P, Pénicaud L, Rampon C, Valet P, Vergnolle N, Andrieu S, de Souto Barreto P, Casteilla L, Vellas B.
  The INSPIRE Bio-Resource Research Platform for Healthy Aging and Geroscience: Focus on the Human Translational Research Cohort (The INSPIRE-T Cohort)
  J Frailty Aging. 2021;10(2):110-120. doi: 10.14283/jfa.2020.38
  2021 Oct

View all publications

Funding

                       

Alumni

• Macarena S. Arrazola (Post-doct 2016; post-doct U. Santiago, Chile),
• Trinovita Andraini (PhD 2017; Assistant Professor, Physiology Department, U. Indonesia, Jakarta),
• Manon Moulis (PhD 2016; post-doc CHU Rangueil Toulouse),
• Thomas Delerue (PhD 2015; post-doc NIH Washington DC, USA),
• Aurélie Millet (PhD 2014); post-doc UCL),
• Ambre Bertholet (PhD 2011; post-doc UCSF, USA),
• Alan Diot (PhD 2011; post-doc Cambridge UK, ENS Lyon),
• Farnoosh Khosrobakhsh (PhD 2010; Assistant Professor, U. of Kurdistan, Iran).