MItochondria- & ExperieNce- Dependent neuronal plastIcity, NeurodeGeneration (MINDING)

Pascale Belenguer

05 61 55 62 38

Team members

  Research engineer
  • Marlène Botella
  • Pascale Belenguer
  • Noélie Davezac
  • Catherine Mollereau-Manaute
  Associate professor
  • Marie-Christine Miquel
  • Laetitia Pelloquin-Arnaune
  PhD student
  • Djamaa Atamena
  • Zahra Ghasemi Abyazani
  Master student
  • Héloïse Guénon


A mitochondrial gate to neuronal plasticity and neurodegeneration.

Finely tuned mitochondrial functions, from energy supply to cell homeostasis, are vital for highly specialized and energy-demanding cells, like neurons. A precise dynamics of mitochondrial fusion and fission events underlies their quality control and adaptability to cellular needs. As an illustration, pathologies directly associated to mutations in key fusion proteins, like Type 1 Dominant Optic Atrophy (OPA1 mutation), are mainly neurodegenerative. Reciprocally, progressive neurodegenerative diseases such as Alzheimer’s are linked not only to impairments of mitochondrial functions (energy, oxidative stress) but also to impairments of mitochondrial dynamics and turn-over.

Mainly centered on in vitro and in vivo DOA models, our projects aim at deciphering, and in fine modeling, the mechanisms of mitochondrial impact on neuronal homeostasis and synaptic plasticity. Spanning from adult neurogenesis to axonal degeneration, we also want to understand the impact of mitochondrial morphological and functional plasticity on experience-dependent neuronal plasticity and complex brain functions such as animal cognition.

Collaborators :

  • Claire Rampon, Lionel Mouledous, Sébastien Lopez (CBI-CRCA), Camille Lejards (CBI-CRCA),
  • Raffele Leva (CBI-LMGM),
  • Joel Bordeneuve-Guibé (ISAE-Supaero, Toulouse),
  • Daniel Dunia (CPTP, Toulouse),
  • Jean-Michel Peyrin (IBPS, Paris),
  • Pascal Reynier (CHU Angers, France),
  • Laurent Roybon (Lundt, Sweden),
  • Bernd Wissinger (U. Tubingen, Germany)



Protective potential of the X protein in DOA (DOAX)

Mitophagy or Apoptosis: a choice Made in neurons by Bnip3-Opa1 interaction ? (MAMBO)

Mitochondria and Axonal degeneration in DOA: a story of shape and function.

Mitochondria, adult neurogenesis & learning and memory (MITOGATE)


View all publications




  • Macarena S. Arrazola (Post-doct 2016; post-doct U. Santiago, Chile),
  • Trinovita Andraini (PhD 2017; Assistant Professor, Physiology Department, U. Indonesia, Jakarta),
  • Manon Moulis (PhD 2016; post-doc CHU Rangueil Toulouse),
  • Thomas Delerue (PhD 2015; post-doc NIH Washington DC, USA),
  • Aurélie Millet (PhD 2014); post-doc UCL),
  • Ambre Bertholet (PhD 2011; post-doc UCSF, USA),
  • Alan Diot (PhD 2011; post-doc Cambridge UK, ENS Lyon),
  • Farnoosh Khosrobakhsh (PhD 2010; Assistant Professor, U. of Kurdistan, Iran).

Université Paul Sabatier
118 Route de Narbonne

31062 TOULOUSE Cedex

05 61 33 58 00

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