Cell-cell communication in the mammalian nervous system

Presentation

Research in the team focuses on elucidating mechanisms that govern development of the nervous system and how genetic alterations of this complex developmental program may lead to brain disease in the adult. 
We investigate cell-to-cell communication via the Eph/ephrin signaling pathway, mostly in the context of neurogenesis and neural progenitor specification and maintenance. Our studies combine in vivo experimentations on genetic mouse models, ex vivo experimentations on tissue explants and in vitro cultures of primary neural progenitors, brain tumor stem cells and cell lines.  

Projets

Calcium signaling

Exploring parallels between neural progenitors and brain tumor stem cells

Investigating specification of neural progenitor fates

Publications

• Fawal MA, Jungas T and Davy A.
  Inhibition of DHFR targets the self-renewing potential of brain tumor initiating cells
  Cancer Letters
  2021 Mar
• Jungas T, Joseph M, Fawal MA and Davy A.
  Population dynamics and neuronal polyploidy in the developing neocortex
  Cerebral Cortex Communications
  2020 Oct
• Kischel, A. Audouard, C. Fawal, MA and Davy, A..
  EphrinB2 paces neuronal production in the developing neocortex
  BMC Dev Biol
  2020 May
• Fawal MA and Davy A.
  Impact of Metabolic Pathways and Epigenetics on Neural Stem Cells.
  Epigenetics Insights
  2019 Jan
• Isabelle Néant, Jacques Haiech, Marie-Claude Kilhoffer, Francisco J. Aulestia, Marc Moreau, Catherine Leclerc.
  Ca2+-dependent transcriptional repressors KCNIP and regulation of prognosis genes in glioblastoma.
  Frontiers in Molecular Neuroscience
  2018 Dec

View all publications

Funding

     

Alumni

KISCHEL Anthony (PhD 2015-2019)

LAUSSU Julien (PhD 2011-2015)> postdoc CRBM, Montpellier, France

ARVANITIS Constandina (postdoc 2007-2010, CR1 2010-2014)> I2MC, Toulouse

LUXEY Maëva (PhD 2007-2011)> Project leader Basel University, Switzerland

BEHAR Annie, AI (CDD 2008-2010)