Presentation
Research in the team focuses on elucidating mechanisms that govern development of the nervous system and how genetic alterations of this complex developmental program may lead to brain disease in the adult.
We investigate cell-to-cell communication via the Eph/ephrin signaling pathway, mostly in the context of neurogenesis and neural progenitor specification and maintenance. Our studies combine in vivo experimentations on genetic mouse models, ex vivo experimentations on tissue explants and in vitro cultures of primary neural progenitors, brain tumor stem cells and cell lines.
Projets
Available PhD project in mechanics of neocortex development
Available PhD project in neurogenesis and metabolism
Elaborating a theoretical framework of neocortex development
Exploring parallels between neural progenitors and brain tumor stem cells
Investigating specification of neural progenitor fates
Publications
- Kischel, A. Audouard, C. Fawal, MA and Davy, A..
EphrinB2 paces neuronal production in the developing neocortex
BMC Dev Biol
2020 May - Fawal MA and Davy A.
Impact of Metabolic Pathways and Epigenetics on Neural Stem Cells.
Epigenetics Insights
2019 Jan - Isabelle Néant, Jacques Haiech, Marie-Claude Kilhoffer, Francisco J. Aulestia, Marc Moreau, Catherine Leclerc.
Ca2+-dependent transcriptional repressors KCNIP and regulation of prognosis genes in glioblastoma.
Frontiers in Molecular Neuroscience
2018 Dec - Aulestia FJ, Néant I, Dong J, Haiech J, Kilhoffer MC, Moreau M, Leclerc C..
Quiescence status of glioblastoma stem-like cells involves remodelling of Ca2+ signalling and mitochondrial shape.
Scientific Reports
2018 Jul - Fawal MA, Jungas T, Kischel A, Audouard C, Iacovoni JS and Davy A.
Crosstalk between one carbon metabolism, eph signaling and histone methylation promotes neural stem cells differentiation
Cell Reports
2018 Jun 
View all publications
Funding
Alumni
KISCHEL Anthony (PhD 2015-2019)
LAUSSU Julien (PhD 2011-2015)> postdoc CRBM, Montpellier, France
ARVANITIS Constandina (postdoc 2007-2010, CR1 2010-2014)> I2MC, Toulouse
LUXEY Maëva (PhD 2007-2011)> Project leader Basel University, Switzerland
BEHAR Annie, AI (CDD 2008-2010)
