Research in the team focuses on elucidating mechanisms that govern development of the nervous system and how genetic alterations of this complex developmental program may lead to brain disease in the adult.
We investigate cell-to-cell communication via the Eph/ephrin signaling pathway, mostly in the context of neurogenesis and neural progenitor specification and maintenance. Our studies combine in vivo experimentations on genetic mouse models, ex vivo experimentations on tissue explants and in vitro cultures of primary neural progenitors, brain tumor stem cells and cell lines.
Astrocyte diversity in the brain
Exploring parallels between neural progenitors and brain tumor stem cells
Investigating specification of neural progenitor fates
- Roussat M, Jungas T, Audouard C, Omerani S, Medevielle F, Agius E, Davy A, Pituello F and Bel-Vialar S..
Control of G2 Phase duration by CDC25B modulates the switch from direct to indirect neurogenesis in the neocortex.
Journal of Neuroscience
- Badouel C., Audouard C. and Davy A. .
Heterogeneity in the size of the apical surface of cortical progenitors
- Ohayon D, Aguirrebengoa M, Escalas N, Jungas T, Soula C .
Transcriptome profiling of the Olig2-expressing astrocyte subtype reveals their unique molecular signature.
- Defourny J, Audouard C, Davy A, Thiry M..
Efnb2 haploinsufficiency induces early gap junction plaque disassembly and endocytosis in the cochlea
Brain Res Bull.
- Fawal MA, Jungas T and Davy A.
Inhibition of DHFR targets the self-renewing potential of brain tumor initiating cells
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LECLERC Catherine (CR 2017- 2022)
BADOUEL Caroline (postdoc 2017-2021)
FAWAL Mohamad (postdoc 2015-2021)> project leader Synaxis
KISCHEL Anthony (PhD 2015-2019)> postdoc Sieć Badawcza Łukasiewicz, Wrocław, Poland
LAUSSU Julien (PhD 2011-2015)> postdoc CRBM, Institut Clément Ader, Toulouse, France
ARVANITIS Constandina (postdoc 2007-2010, CR1 2010-2014)
LUXEY Maëva (PhD 2007-2011)> Project Leader, Basel University, Switzerland
BEHAR Annie, AI (CDD 2008-2010)